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Forum on Immunopathological Diseases and Therapeutics

ISSN Print: 2151-8017
ISSN Online: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2016018185
pages 33-40

Gut Microbiota: Potential Impact on Chemotherapy-Related Adverse and Therapeutic Effects

Yann Touchefeu
Institut des Maladies de l'Appareil Digestif, Centre Hospitalier Universitaire de Nantes, France
M. Salimon
Institut des Maladies de l'Appareil Digestif, Centre Hospitalier Universitaire de Nantes, France
E. Montassier
Faculte de Medecine, Laboratoire EA 3826, Therapeutiques Cliniques et Experimentales des Infections, Universite de Nantes, France

ABSTRACT

Gut microbiota have a key role in the maintenance of intestinal integrity, but chemotherapy can induce major changes in the composition and gene function of gut microbiota. Such modifications may contribute to the development of gastrointestinal mucositis. The prevention of cancer therapy−induced mucositis has been investigated in clinical trials with promising results. The role of gut microbiota is important not only in the development of adverse events but also for immune-related therapeutic effects. Thus, gut microbiota may be an essential partner of chemotherapy in improving patient outcomes.