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Cross-Regulation Between WNT and NF-κB Signaling Pathways

Volume 1, Issue 3, 2010, pp. 155-181
DOI: 10.1615/ForumImmunDisTher.v1.i3.10
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Qiang Du
Department of Surgery, T.E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
David Geller
University of Pittsburgh

ABSTRACT

Cross-regulation between the Wnt and nuclear factor (NF)-κB signaling pathways has emerged as an important area for the regulation of a diverse array of genes and pathways active in chronic inflammation, immunity, development, and tumorigenesis. The ligands, kinases, transcription factors, and products of their target gene expression are involved in cross-regulation of these two signaling pathways. Both β-catenin and NF-κB activate inducible nitric oxide synthase (iNOS) gene expression; however, β-catenin also exerts an inhibitory effect on NF-κB-mediated transcriptional activation, including iNOS. The recent discovery of functional cross-regulation between these two pathways has shown complex roles for Wnt/β-catenin and NF-κB signaling in the pathogenesis of certain cancers and other diseases. This review focuses on the molecular mechanisms of cross-regulation between Wnt/β-catenin and NF-κB signaling pathways in cancer cells.

KEY WORDS: Wnt signaling pathway, NF-κ, B signaling pathway, cross-regulation, β, -catenin
CITED BY

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