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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.309 SNIP: 0.041 CiteScore™: 0.18

ISSN Print: 2151-8017
ISSN Online: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2014008421
pages 213-218

Use of Botulinum Neurotoxin in Cranial Nerve Paralysis due to Nasopharyngeal Carcinoma

Ozge Ilhan-Sarac
Department of Ophthalmology, Ankara Ataturk Research and Training Hospital, Ankara, Turkey
Hande Taylan Sekeroglu
Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
Ali Sefik Sanac
Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey
Enis Ozyar
Department of Radiation Oncology, Acibadem University School of Medicine, Istanbul, Turkey
Cumhur Sener
Department of Ophthalmology, Hacettepe University School of Medicine, Ankara, Turkey

ABSTRACT

Nasopharyngeal carcinoma (NPC) is a malignant tumor of the nasopharynx arising from the epithelial cells. Extension of the primary tumor to the adjacent tissues can cause cranial nerve (CN) palsies. Although all CNs can be involved, the CN VI, CN V, CN VIII, CN IX, and CN XII are the most commonly affected. Isolated involvement frequently occurs in the CN V or CN VI. Nearly 70% of patients with CN palsy associated with NPC show improvement after radiotherapy. The recovery duration is generally within 6 months; therefore, botulinum neurotoxin injection should be considered for these patients to alleviate the complaints within this time period.


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