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Targeting PGE2 Signaling in Tumor Progression and Angiogenesis

Volume 5, Issue 3-4, 2014, pp. 223-232
DOI: 10.1615/ForumImmunDisTher.2015014095
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ABSTRACT

Inflammatory milieu is associated with cancer progression and angiogenesis in different types of tumors, such as gastrointestinal, breast, prostate, and head and neck cancers. Among the inflammatory pathways, numerous evidence indicates that the cyclooxygenase-2/microsomal prostaglandin E synthase-1/prostaglandin E2/E Prostaglandin type receptor (COX-2/mPGES-1/PGE2/EPs) signaling supports epithelial tumor aggressiveness promoting cell growth, epithelial-mesenchymal transition (EMT), and sternness. Further, PGE2 modulates pro-oncogenic and pro-angiogenic pathways such as EGFR and FGFR-1. In this review, we discuss the role of PGE2 and its network of partner proteins in tumor progression and angiogenesis. We also discuss major COX-2/mPGES-1 and EPs therapeutic advances that have been made over the past few years in targeting tumorigenesis and angiogenesis.

CITED BY
  1. Finetti Federica, Travelli Cristina, Ercoli Jasmine, Colombo Giorgia, Buoso Erica, Trabalzini Lorenza, Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity, Biology, 9, 12, 2020. Crossref

  2. Babu R. Swethan, Palaniappan Senthilkumar, Kathiravan M.K., Synthesis and Anticancer Activity of Novel Thiazolo-Coumarin Derivatives, Asian Journal of Chemistry, 35, 1, 2023. Crossref

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