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Forum on Immunopathological Diseases and Therapeutics
SJR: 0.164 SNIP: 0.041 CiteScore™: 0.18

ISSN Print: 2151-8017
ISSN Online: 2151-8025

Archives: Volume 1, 2010 to Volume 7, 2016

Forum on Immunopathological Diseases and Therapeutics

DOI: 10.1615/ForumImmunDisTher.2013008317
pages 53-62

Modulation of Tumor–Stromal Cell Interactions: A New Anti-Tumor Strategy Targeting the Tumor Microenvironment

Manabu Kawada
Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, Japan
Shuichi Sakamoto
Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, Japan
Akio Nomoto
Institute of Microbial Chemistry (BIKAKEN), Numazu, Microbial Chemistry Research Foundation, Shizuoka, Japan

ABSTRACT

Tumor tissues are composed of tumor cells as well as the surrounding stroma. The stroma consists of various kinds of cells and the extracellular matrix that together form the tumor microenvironment. Among them, stromal cells (fibroblast-like cells) can regulate the growth of tumor cells positively or negatively through the tumor–stromal cell interactions (TSIs). TSIs are mediated by secreted factors or direct adhesion. Thus, the growth of tumor cells may be able to be suppressed by modulation of TSIs. In this review, we introduce new strategies targeting the tumor microenvironment, especially TSIs. Molecular targets in TSIs and small molecule compounds that can modulate TSIs are discussed.


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