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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v16.i6.50
pages 451-457

Surfactant Induced Glistenings: Surface Active Ingredients in Ophthalmic Solutions May Enhance Water Entry into the Voids of Implanted Acrylic Intraocular Lenses

Masahiko Ayaki
Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Japan
Hitoshi Nishihara
Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Japan
Shigeo Yaguchi
Department of Ophthalmology, Fujigaoka Hospital, Showa University School of Medicine, Japan
Ryohei Koide
Department of Ophthalmology, Showa University School of Medicine, Japan

ABSTRACT

Purpose: To investigate the light scattering properties of acrylic intraocular lenses (IOLs) placed in eyes treated with diclofenac sodium (Diclod®, Wakamoto, Japan) and betamethasone phosphate (Rinderon®, Shionogi, Japan) ophthalmic solutions. Methods: The light scattering properties of IOLs (MA30BA, Alcon laboratories) placed in 32 eyes treated with Diclod® and 31 treated with Rinderon® were evaluated 3 years after implantation using Scheimpflug photography. Results: The averaged intensity of glistenings was 9.0 CCT (computer compatible tapes) in the Diclod® test group and 4.2 CCT in the Rinderon® test group (p = 0.002). The intensity of surface light scattering for the Diclod® and Rinderon® test groups was 24.0 CCT and 26.9 CCT, respectively (p = 0.081). Conclusion: The Diclod® test group had a greater number of glistenings than the Rinderon® test group. Both drugs have similar anti-inflammatory properties and Diclod®, unlike Rinderon®, also contains the surfactant polysorbate. We proposed that the presence of surfactant, or other ingredient, in commercially available eyedrops may enhance the development of glistenings.