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ISSN Print: 1050-6934
ISSN Online: 1940-4379
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Effects of Prosthetic Materials on the Host Immune Response: Evaluation of Polymethyl-methacrylate (PMMA), Polyethylene (PE), and Polystyrene (PS) Particles
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ABSTRACT
The main causes for the long-term prosthetic implants' failure are the body's reaction to the implanted material or mechanical stress on the device resulting in the formation of wear particles. Particulate wear debris attracts macrophages, and depending on the chemical composition of the material and particle size, various levels of inflammatory response may occur. While transient inflammation is common, development of chronic inflammation may have serious consequences, leading to implant failure. Such a process may also cause systemic changes to immune functions and long-term effects on the host immune responses. In this study, we evaluated the effects of polystyrene (PS), polyethylene (PE), and polymethylmethacrylate (PMMA) particles on macrophage function and the generation of T-cell responses. Particles of various diameters were injected intraperitoneally into Balb/c mice, and immune functions were examined at 3, 10, and 21 days after the injection. The intensity of phagocytosis by peritoneal exudate cells (PECs) and the proliferative response of spleen cells from treated mice were evaluated. Enumeration of PECs revealed an increase in the total number of cells. Mice injected with PS or PE particles had a higher percentage of cells containing particles than PMMA-injected mice. Macrophages with PS or PE particles tended to adhere to and/or infiltrate peritoneal fibro-fatty tissues surrounding the spleen and pancreas, while the PMMA-carrying macrophages infiltrated the spleen, resulting in an increase of spleen size and "weight. The spleen cell proliferation assay revealed only mild and transient effects on the mitogen response in both PE and PS particle-injected mice. However, in the PMMA-injected mice we observed a lasting increase of the Con A response and a decrease of the LPS response. In vitro exposure of PECs from untreated mice showed a dose-response pattern in nitric oxide (NO) and TNFα production. While exposure to either PMMA or PE induced comparable levels of NO, exposure to PMMA induced a markedly higher production ofTNFα than exposure to PE.The results indicate that particulate biomaterials may, in addition to the initial activation of phagocytes, significantly affect immune functions and compromise the host response to other antigenic stimuli.
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Moretti Ana I.S., Souza Pinto Francisco J.P., Cury Vivian, Jurado Marcia C., Marcondes Wagner, Velasco Irineu T., Souza Heraldo P., Nitric oxide modulates metalloproteinase-2, collagen deposition and adhesion rate after polypropylene mesh implantation in the intra-abdominal wall, Acta Biomaterialia, 8, 1, 2012. Crossref
-
Akilbekova Dana, Philiph Rachel, Graham Austin, Bratlie Kaitlin M., Macrophage reprogramming: Influence of latex beads with various functional groups on macrophage phenotype and phagocytic uptakein vitro, Journal of Biomedical Materials Research Part A, 103, 1, 2015. Crossref
-
Stratmeyer Mel E., Goering Peter L., Hitchins Victoria M., Umbreit Thomas H., What we know and don’t know about the bioeffects of nanoparticles: developing experimental approaches for safety assessment, Biomedical Microdevices, 12, 4, 2010. Crossref
-
Ament Jared D, Spurr-Michaud Sandra J, Dohlman Claes H, Gipson Ilene K, The Boston Keratoprosthesis: Comparing Corneal Epithelial Cell Compatibility with Titanium and PMMA, Cornea, 28, 7, 2009. Crossref
-
Charles Julia F., Nakamura Mary C., Bone and the Innate Immune System, Current Osteoporosis Reports, 12, 1, 2014. Crossref
-
Lalor P.A., Jones L.C., The Innate Response to Biomaterials, in Comprehensive Biomaterials, 2011. Crossref
-
Teeter Matthew G, Langohr G Daniel G, Medley John B, Holdsworth David W, Nondestructive microimaging during preclinical pin-on-plate testing of novel materials for arthroplasty, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228, 2, 2014. Crossref
-
Lalor P.A., Jones L.C., 4.3 The Innate Response to Biomaterials ☆, in Comprehensive Biomaterials II, 2017. Crossref
-
Smith Walter Ryan, Hudson Parke William, Ponce Brent Andrew, Rajaram Manoharan Sakthivel Rajan, Nanotechnology in orthopedics: a clinically oriented review, BMC Musculoskeletal Disorders, 19, 1, 2018. Crossref
-
Zhu Kechao, Yang Chao, Dai Huiyong, Li Juehong, Liu Wei, Luo Yao, Zhang Xianlong, Wang Qi, Crocin inhibits titanium particle-induced inflammation and promotes osteogenesis by regulating macrophage polarization, International Immunopharmacology, 76, 2019. Crossref
-
Buruga Kezia, Kalathi Jagannathan T., Synthesis of poly(styrene-co-methyl methacrylate) nanospheres by ultrasound-mediated Pickering nanoemulsion polymerization, Journal of Polymer Research, 26, 9, 2019. Crossref
-
Xie Xiang, Zhang Qingyi, Zhang Ping, Zhou Huan, Zhang Ran, Wang Xudong, Li Yanming, Particulate poly(methyl methacrylate) could stimulate proinflammatory CD4 T cell responses in a monocyte-dependent manner, and directly mediate cell death, Human Immunology, 80, 12, 2019. Crossref
-
Krenzlin Harald, Foelger Andrea, Mailänder Volker, Blase Christopher, Brockmann Marc, Düber Christoph, Ringel Florian, Keric Naureen, Novel Biodegradable Composite of Calcium Phosphate Cement and the Collagen I Mimetic P-15 for Pedicle Screw Augmentation in Osteoporotic Bone, Biomedicines, 9, 10, 2021. Crossref
-
Simpson Fiona C., McTiernan Christopher D., Islam Mohammad Mirazul, Buznyk Oleksiy, Lewis Philip N., Meek Keith M., Haagdorens Michel, Audiger Cindy, Lesage Sylvie, Gueriot François-Xavier, Brunette Isabelle, Robert Marie-Claude, Olsen David, Koivusalo Laura, Liszka Aneta, Fagerholm Per, Gonzalez-Andrades Miguel, Griffith May, Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs, Communications Biology, 4, 1, 2021. Crossref
-
Vernon Brian A., Bollinger Alexander J., Garvin Kevin L., McGarry Sean V., Osteolytic Lesion of the Tibial Diaphysis After Cementless TKA, Orthopedics, 34, 3, 2011. Crossref
-
Eriksson Peter, Truong Anh H.T., Brommesson Caroline, du Rietz Anna, Kokil Ganesh R., Boyd Robert D., Hu Zhangjun, Dang Tram T., Persson Per O. A., Uvdal Kajsa, Cerium Oxide Nanoparticles with Entrapped Gadolinium for High T1 Relaxivity and ROS-Scavenging Purposes, ACS Omega, 7, 24, 2022. Crossref
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GÜNEŞ Eda, ERÇETİN Haticetül Kübra, Çimlendirilme ortamına göre brokoli filizinin in vivo etkisinin belirlenmesi, Gümüşhane Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022. Crossref
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Sadanandan Bindu, Vaniyamparambath Vijayalakshmi, Lokesh K. N., Shetty Kalidas, Joglekar Amruta P., Ashrit Priya, Hemanth Beena, Candida albicans biofilm formation and growth optimization for functional studies using response surface methodology , Journal of Applied Microbiology, 132, 4, 2022. Crossref
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Ogbodo John Onyebuchi, Arazu Amarachukwu Vivan, Iguh Tochukwu Chisom, Onwodi Ngozichukwuka Julie, Ezike Tobechukwu Christian, Volatile organic compounds: A proinflammatory activator in autoimmune diseases, Frontiers in Immunology, 13, 2022. Crossref
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Ashrit Priya, Sadanandan Bindu, Kyathsandra Natraj Lokesh, Shetty Kalidas, Vaniyamparambath Vijayalakshmi, Raghu Anjanapura V., A microplate‐based Response Surface Methodology model for growth optimization and biofilm formation on polystyrene polymeric material in a Candida albicans and Escherichia coli co‐culture , Polymers for Advanced Technologies, 33, 9, 2022. Crossref
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Tian Xinggui, Raina Deepak B., Vater Corina, Kilian David, Ahlfeld Tilman, Platzek Ivan, Nimtschke Ute, Tägil Magnus, Lidgren Lars, Thomas Alexander, Platz Uwe, Schaser Klaus-Dieter, Disch Alexander C., Zwingenberger Stefan, Evaluation of an Injectable Biphasic Calcium Sulfate/Hydroxyapatite Cement for the Augmentation of Fenestrated Pedicle Screws in Osteoporotic Vertebrae: A Biomechanical Cadaver Study, Journal of Functional Biomaterials, 13, 4, 2022. Crossref