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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.2016016396
pages 199-204

Comparison of Two Regenerative Surgical Treatments for Peri-Implantitis Defect using Natix Alone or in Combination with Bio-Oss and Collagen Membrane

Hamid Reza Arab
Oral and Maxillofacial Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Farid Shiezadeh
Department of Periodontics, Mashhad University of Medical Sciences, Mashhad, Iran
Amir Moeintaghavi
Dental Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Najme Anbiaei
Oral and Maxillofacial Diseases Research Center, Department of Oral and Maxillofacial Radiology, University of Medical Sciences, Mashhad, Iran
Satlikh Mohamadi
Periodontist in Private Practice


The aim of this clinical trial was to evaluate 6-month clinical and radiographic outcomes after surgical regenerative therapy of peri-implantitis lesions using either porous titanium granules (Natix, Tigran Technologies, Malmo, Sweden) alone or bovine bone mineral (Bio-Oss, Giestlich, Wolhusen, Switzerland) with a collagen membrane (B&B Dental Implant Company, San Pietro, Italy). Twenty-four patients having at least one implant with a peri-implantitis lesion were involved in this study. Patients were assigned randomly into two groups and treated with two different regenerative approaches. The first group (Group 1) received Natix alone and the second group (Group 2) received Bio-Oss plus collagen membrane after debridement of the defect. Probing depth, clinical attachment level, and radiographic measurements were recorded at baseline and after 6 months of healing. One patient with one implant from Group 1 and another patient with 2 implants from the Group 2 discontinued the study. Mean pocket depth change was 1.1 ± 1.4 mm in Group 1 and 1.1 ± 2.1 mm in Group 2. Bone level changes were 0.85 ± 1.06 and 1.4 ± 1.04 mm in the two groups, respectively, over the 6-month follow-up period. Neither clinical nor radiographical differences between the two groups were statistically significant. We conclude that both application of porous titanium granules and Bio-Oss plus collagen membrane resulted in clinical improvement of peri-implantitis lesions over a period of 6 months.