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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v21.i4.60
pages 321-337

The Human Knee Meniscus: A Review with Special Focus on the Collagen Meniscal Implant

Robert (Trey) Hansen
Kingsbrook Jewish Medical Center, New York, NY 10038
Gene Choi
Kingsbrook Jewish Medical Center, New York, NY 10038
Eli Bryk
Kingsbrook Jewish Medical Center, New York, NY 10038
Vincent J. Vigorita
Department of Pathology, State University of New York (SUNY), Downstate Medical Center, Brooklyn, New York, USA

ABSTRACT

The human knee meniscus is important for the protection of the knee joint from degeneration. Because it is so commonly injured, several methods have been developed to replace damaged meniscal tissue with either transplanted menisci or other synthetic implants. Here we review these different approaches, with a clinical and histological focus on the collagen meniscal implant (CMI or Menaflex), a tissue-engineered bovine collagen product. Clinical trials in patients receiving the CMI have demonstrated good clinical outcomes in follow-ups as long as 10 years. We review the findings of second-look biopsies of implanted CMI constructs; they demonstrate the fibrochondrocytic ingrowth of tissue mimicking a native meniscus. Integration of the CMI to host meniscus is also confirmed. The histologic inflammation occasionally observed around the graft appears to be of little clinical significance. We conclude that tissue-engineered menisci from bovine collagen are safe in the time period examined and that they hold promise for future repair of the meniscus in appropriate individuals.


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