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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v20.i4.40
pages 295-301

Medical-Grade Calcium Sulfate Hemihydrate in Clinical Implant Dentistry: A Review

Ahmad Kutkut
SUNY at Buffalo School of Dental Medicine
Sebastiano Andreana
University at Buffalo, School of Dental Medicine


Medical-grade calcium sulfate has been successfully used for several decades as a bone filler and as a carrier with medications or bone growth factors for the treatment of bone defects. The present review illustrates the biological behavior and clinical outcomes of this material when used in clinical implant dentistry. Furthermore, the review illustrates the different indications specifically related to implant dentistry when medical-grade calcium sulfate has been used alone or in combination with bone grafting materials. The histological published evidence is reviewed together with successful clinical results. This material, well known since the 1800s, continues to be used by clinicians and researchers worldwide, and the latest scientific evidence clearly indicates that medical-grade calcium sulfate can be used alone or in combination with biologically active proteins in applications such as socket preservation, ridge augmentation, and sinus lift procedures.