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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.2013007073
pages 9-16

MiR146a and MiR499 Gene Polymorphisms in Iranian Periodontitis and Peri-implantitis Patients

Mahdi Kadkhodazadeh
Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ali Reza Jafari
Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reza Amid
Dental Research Center, Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ahmad Reza Ebadian
Dentist, Private practitioner, Aref St., Mashhad, Iran
Marjan Mohammad Alipour
Dental School, Shahid Beheshti University of Medical
Fatemeh Mollaverdi
Operative Dentistry Department, Dental School, Shahed University, Tehran, Iran
Ardeshir Lafzi
Periodontics Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

ABSTRACT

Aim: MicroRNAs (MiRs) are small noncoding RNAs that are involved in protein translation, osteoclastogenesis, and immunoregulation. Peri-implantitis and chronic periodontitis are multifactorial diseases. They are the consequence of complex interactions among host response, genetics, and environment. In the present study, we aimed to investigate the possible association between MiR146a/MiR499 gene polymorphisms and periodontitis/peri-implantitis as a first report in oral implantology.
Methods: From 197 individuals referred to Periodontology Department of Shahid Beheshti Dental School, three groups were enrolled in the assessment: 75 patients in the chronic periodontitis (CP) group, 38 patients in the peri-implantitis (PI) group, and 84 healthy subjects. DNA was extracted from fresh blood samples from the arm veins of participants and transferred to KBiosience Institute (Hoddesdon, United Kingdom) for genotyping. Chi-squared and Kruskal-Wallis tests were performed using SPSS software v.19 for statistical analyses. P-value < 0.05 was considered significant.
Results: The genotype frequencies in MiR 146a and MiR 499 were significantly different among the three groups.
Conclusions: MiR146a (rs2910146) and MiR499 (rs3746444) gene polymorphisms may be genetic determinants for increased risk of chronic periodontitis and peri-implantitis in Iranians. More studies with larger sample sizes in different populations are necessary for determining the effect of these SNPs.