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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v10.i12.110
15 pages

Protein Interactions with Endovascular Prosthetic Surfaces

Cristina Simon
The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78284-7800
Julio C. Palmaz
The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio TX 78284-7800
Eugene Sprague
The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio TX 78284-7800

ABSTRACT

Blood protein interaction with prosthetic surfaces seems to be the initial step in the chain of events leading to tissue incorporation of endovascular devices. This paper focuses on the relationship between surface free energy and protein adsorption on metals and polymers commonly used for fabricating vascular prosthetic devices. Our results support a relationship between surface energy and protein adsorption. Albumin was more easily eluted than fibrinogen and fibronectin from most metals and all polymeric surfaces considered. Following elution, metals retained a larger fraction of protein as compared to polymers.