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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v11.i12.70
8 pages

Fibrin Sealants in Microvascular Surgery: Current Status

David B. Drake
Associate Professor of Plastic Surgery & Orthopedic Surgery. University of Virginia Health System PO Box 800376 Charlottesville VA 22908-0376, USA
Robert E. H. Ferguson, Jr.
Department of Plastic Surgery, University of Virginia School of Medicine, Box 800376, Charlottesville, VA 22908


During the last two decades, advances in fibrin sealant formulation have resulted in its investigational and clinical use in various surgical endeavors, including microvascular surgery. Several investigations have comparatively evaluated fibrin adhesive-enhanced microvascular anastomoses vs. conventional suture repair. The purpose of this review is to summarize the collective documentation on fibrin adhesives in microvascular surgery on the basis of the scientific performance parameters of vessel patency, bursting strength, anastomotic competence, and reendothelialization. In addition, other applications of fibrin sealants and other qualities unique to fibrin adhesives are addressed.