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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v16.i1.70
pages 61-69

Collective Review: Bioactive Implants Coated with Poly(D,L-lactide) and Growth Factors IGF-I, TGF-β1, or BMP-2 for Stimulation of Fracture Healing

Gerhard Schmidmaier
Center for Musculoskeletal Surgery, Charité, University Medicine, Berlin, Germany
Martin Lucke
Center for Musculoskeletal Surgery, Charité, University Medicine, Berlin, Germany
Philipp Schwabe
Center for Musculoskeletal Surgery, Charité, University Medicine, Berlin, Germany
Michael Raschke
Department Trauma, Hand and Reconstructive Surgery, University Hospital, Muenster, Germany
Norbert P. Haas
Center for Musculoskeletal Surgery, Charité, University Medicine, Berlin, Germany
Britt Wildemann
Center for Musculoskeletal Surgery, Charité, University Medicine, Berlin, Germany

ABSTRACT

Demographic data reveal that due to the increasing aging of the population, complications with the musculoskeletal system will increase in the next years. One major problem in orthopedic and trauma surgery are the delayed healing or non-unions of long bone fractures. The exogenous application of growth factors can stimulate the bone healing to reduce these complications. Beside the choice of the optimal growth factor the application system is important. Therefore, we developed a new bioactive coating method for implants, which is based on a biodegradable poly(D,L-lactide) (coating thickness: 10 μm).This coating allows the incorporation of growth factors and the controlled release of these factors during the healing process without the need for further devices. The effect of different growth factors (IGF-I, TGF-β1, and BMP-2) locally released from coated intramedullary implants on fracture healing was investigated with biomechanical and histological analysis in rats.
All investigated growth factors stimulated the fracture healing as assessed with biomechanical tests and histological analysis. The local application of combined IGF-I and TGF-β1 had the most stimulating effect on fracture healing, followed by the effect of BMP-2, IGF-I, and TGF-β1 alone. Bioactive coating of biomechanical well-established implants can on the one hand stabilize the fracture and on the other hand stimulate healing processes to increase healing and to reduce the rate of complications.