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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v19.i4.60
pages 287-304

Side Effects of Radiation in Musculoskeletal Oncology

Andreas F. Mavrogenis
First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece
Panayiotis J. Papagelopoulos
First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece
Matteo Romantini
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna
Giovanni Guerra
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna, Italy
Pietro Ruggieri
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna

ABSTRACT

Radiation therapy is applied for systemic effects to patients with bone and soft tissue tumors and for local effects that facilitate the surgical procedure. However, while it remains an essential treatment of cancers, radiation therapy is associated with unwanted complications. The purpose of this review is to summarize information regarding the complications of radiation in musculoskeletal oncology and their management. Because preoperative radiotherapy is associated with an increased risk of wound complications and postoperative radiation is associated with an increased risk of postradiation fractures, the physician requires additional information in deciding on the best method of treatment, and such information is provided in this review.