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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v10.i4.60
12 pages

Tissue Expander: Histological and Histochemical Study 6 Months After Transplant—Our Experience

Giordano Stabellini
lnstituto di Anatomia Umana Normale, Universita Statale di Milano, Facolta di Medicina e Chirurgia, Via Mangiagalli, 31, 20133 Milano, Italy
Carla Calastrini
Dipartimento di Morfologia ed Embriologia, Sezione di Istologia ed Embriologia Universita di Ferrara, Italy
Anna Marcucci
lnstituto di Anatomia Umana Normale, Universita Statale di Milano, Facolta di Medicina e Chirurgia, Via Mangiagalli, 31, 20133 Milano, Italy
Monica De Mattei
Dipartimento di Morfologia ed Embriologia, Sezione di Istologia ed Embriologia Universita di Ferrara, Italy
Maria I. Luna-Carbonel
Unita Operativa Chirurgia Pediatrica, Azienda Ospedaliera Arcispedale S. Anna, Ferrara, Unita Operativa Primario Dott. A. Franchella, Italy
Agnese Pellati
Dipartimento di Morfologia ed Embriologia, Sezione di Istologia ed Embriologia Universita di Ferrara, Italy
Giustiniano Mariani
Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Italy
Andrea Franchella
Unita Operativa Chirurgia Pediatrica, Azienda Ospedaliera Arcispedale S. Anna, Ferrara, Unita Operativa Primario Dott. A. Franchella, Italy

ABSTRACT

Implanting an expander in the subcutaneous layer causes gradual expansion and provides additional tissue for reconstruction of tissular defects. The force applied remodels the connective tissue and modifies dermis contractibility in additional tissue. Other authors confirm that parameters such as mitosis and hyaluronan influence the system in the tissue regeneration processes.8,9 We studied histochemical and morphological variations of tissue expanders before and 6 months after transplant. Our histochemical data do not show any changes in dermis glycosaminoglycans of the expanded and transplant-expanded skin when compared to controls. Morphological data demonstrate reorganization of connective fibers and disappearance of the papillar layer. The latter is not yet formed in the expanded skin 6 months after transplant. This suggests that a long time is required for biological reconstruction of epidermal-dermal interactions after transplant.