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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.2013010139
pages 105-149

Conservative Treatments, Surgical Treatments, and the KineSpring® Knee Implant System for Knee Osteoarthritis: A Systematic Review

Chuan Silvia Li
Global Research Solutions, Inc., Burlington, Ontario, Canada; Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Olufemi R. Ayeni
Division of Orthopaedic Surgery, Centre for Evidence-Based Orthopaedics, McMaster University, Hamilton, Ontario, Canada
Sheila Sprague
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; University of Rochester Medical Center, Orthopaedics Department, Rochester, NY
Victoria Truong
Global Research Solutions Inc, Burlington, Ontario, Canada
Mohit Bhandari
CLARITY Research Group, McMaster University, Department of Orthopedic Surgery Musculoskeletal Research Unit, Canada and Division of Orthopaedic Surgery and Department of Clinical Epidemiology & Biostatistics, Hamilton General Hospital, Canada


Purpose: Knee osteoarthritis (OA) is a disease with a high global burden, and multiple treatment options are available. In the current review we summarize the results of studies that have evaluated treatments of knee OA, and we compare these results with an implantable load absorber called the KineSpring® Knee Implant System.
Methods: We conducted a literature search of systematic reviews on treatment strategies for knee OA. We pooled results for each treatment in three categories: pain, function, and stiffness. Then we compared this data to that available for the KineSpring System.
Results: Medications and viscosupplementation show promising initial pain relief for knee OA. Aerobic and resistance training, unicompartmental knee arthroplasty (UKA), and total knee arthroplasty (TKA) showed a reduction in pain scores. High tibial osteotomy (HTO) generally improves pain and function at 6 weeks, but long-term results are lacking. The KineSpring System demonstrated significant improvements from baseline to 24 months, but direct comparative data are lacking.
Conclusions: Evidence for knee OA therapies suggests improved pain, stiffness, and functional outcomes. Additional research is necessary to clearly delineate the advantages of various approaches to guide practice.