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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v12.i1.20
33 pages

Recent Advances in Tissue Engineering: An Invited Review

R. G. Pearson
Tissue Engineering Group, School of Pharmaceutical Sciences, The University of Nottingham, NG7 2RD, UK
R. Bhandari
Tissue Engineering Group, School of Pharmaceutical Sciences, The University of Nottingham, NG7 2RD, UK
R. A. Quirk
RegenTec Ltd., 1 Faraday Building, Science & Technology Park, Nottingham, NG7 2QP, UK
Kevin M. Shakesheff
EPSRC Advanced Fellow. Tissue Engineering Group School of Pharmaceutical Sciences The University of Nottingham Nottingham NG7 2RD United Kingdom

ABSTRACT

Tissue formation within the body, as part of a development or repair process, is a complex event in which cell populations self-assemble into functional units. There is intense academic, medical, and commercial interest in finding methods of replicating these events outside the body. This interest has accelerated with the demonstration of the engineering of skin and cartilage tissue in the laboratory and there is now worldwide activity in the in vitro regeneration of tissues including nerve, liver, bone, heart valves, blood vessels, bladder, and kidney. Approaches to tissue engineering center on the need to provide signals to cell populations to promote cell proliferation and differentiation. This review considers recent advances in methods of providing these signals to cells using examples of progress in the engineering of complex tissues.