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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v12.i2.30
14 pages

DNA-Transfer Approaches in Treatment of Chronic Inflammatory Joint Disease

D. Olga McDaniel
Departments of Surgery and Neurology, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216

ABSTRACT

Chronic inflammatory joint diseases (CIJDs), including rheumatoid arthritis, are .complex inflammatory processes that result in joint damage, pain, deformity, and disability. Established therapies of pain control and anti-inflammatory medications fail to control the disease processes themselves. Gene-therapy strategies may offer therapies that can modify or abort the inflammatory processes attaching joint tissue, and may deliver biologically active DNA to critical morphological and biochemical points in these diseases. Such techniques as cell-mediated transport may allow highly selective treatments for these diseases.