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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v12.i2.70
11 pages

DNA Strand Gene Transfer and Bone Healing

William C. Lineaweaver
Division of Plastic Surgery. The University of Mississippi Medical Center, 2500, North State Street, Jackson, MS 39216-4505
Feng Zhang
Division of Plastic Surgery, Microsurgery Laboratory, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216
Kenneth Fischer
Division of Plastic Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216

ABSTRACT

Continued research is still needed to broaden the understanding of the biology of bone formation, bone repair, and bone remodeling. Preliminary data reviewed in this article confirm that it is possible to use ex vivo and in vrvo gene-transfer strategies to transfer genes to bone and express them in the repair site. As work progresses, strategies of gene therapy with osteoinductive-growth factors may provide the orthopedic surgeon with more effective and less-costly treatment options for bone-healing problems.