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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v11.i34.60
21 pages

Alternative Fixation of Bioprostheses

Marc Hendriks
Medtronic Bakken Research Center, Materials and Biosciences Center, Endepolsdomein 5, 6229 GW Maastricht, The Netherlands
Frank Everaerts
Medtronic Bakken Research Center, Materials and Biosciences Center, Endepolsdomein 5, 6229 GW Maastricht, The Netherlands
Michel Verhoeven
Medtronic Bakken Research Center, Materials and Biosciences Center, Endepolsdomein 5, 6229 GW Maastricht, The Netherlands

ABSTRACT

The glutaraldehyde fixation technique for bioprosthetic tissue valves has been used for about 30 years. It is more or less generally recognized, however, that a solution to the ongoing problems of calcification and immunomodulated inflammation can only be achieved with the development of alternative fixation techniques that differ from fixation with glutaraldehyde. This review reports on the chemistry behind newly developed tissue-fixation processes and the preliminary results achieved with these.