Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v11.i34.90
10 pages

Matrix Metalloproteinases and Tissue Valve Degeneration

Mona Bracher
Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town Medical School, Cape Town, South Africa
Dan Simionescu
Department of Biomedical Research, Mures Heart Centre, Targu Mures, Romania
Agneta Simionescu
Department of Biomedical Research, Mures Heart Centre, Targu Mures, Romania
Neil Davies
Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town Medical School, Cape Town, South Africa
Paul Human
Department of Cardiothoracic Surgery, Cape Heart Centre, University of Cape Town Medical School, Cape Town, South Africa
Peter Zilla
Department of Cardiothoracic Surgery, University of Cape Town, Cape Town, 7925, South Africa

ABSTRACT

Bioprosthetic heart valves have been used as replacements for diseased heart valves for over 30 years. More than 50% of bioprosthetic valves fail within IS years because of structural deterioration. The role of proteolytic degradation, with particular reference to the matrix metalloproteinases (MMPs) in the degeneration of aortic bioprostheses, is appraised in this minireview. It is clear that both the intrinsic and host-derived proteolytic activities present in heart-valve bioprostheses may combine with mechanical stress to bring about valve failure.