ISSN Print: 1050-6934
Volumes:Volume 28, 2018 Volume 27, 2017 Volume 26, 2016 Volume 25, 2015 Volume 24, 2014 Volume 23, 2013 Volume 22, 2012 Volume 21, 2011 Volume 20, 2010 Volume 19, 2009 Volume 18, 2008 Volume 17, 2007 Volume 16, 2006 Volume 15, 2005 Volume 14, 2004 Volume 13, 2003 Volume 12, 2002 Volume 11, 2001 Volume 10, 2000
Journal of Long-Term Effects of Medical Implants
Glutaraldehyde Fixation Revisited
Marcel E. Nimni
Departments of Surgery, Orthopedics and Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033
Our ability to stabilize animal heart valves and to manufacture equivalent prostheses using collagenous tissues has proven to be of significant value to large number of patients over the last 30 years. Such tissue-derived bioprostheses are being gradually improved by modifications of design and slight changes in the processing of the tissues from which they originate. Nevertheless their durability does not seem to have significantly improved, and some of their drawbacks, such as their propensity to calcify, have not been eliminated. Because of this children are excluded from receiving such implants. Enhancing such structures using cells from various sources or with the aid of growth factors does not seem likely to succeed because such inert matrices are not compatible with growth and remodeling. On the other hand, stabilizing these structures by means of novel crosslinking approaches, the addition of "plastisizing" molecules, or the addition of covalently bound residues that inhibit the growth of mineral deposits, could prove to be practical ways of improving such devices.
|Begell Digital Portal||Begell Digital Library||eBooks||Journals||References & Proceedings||Research Collections|