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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v20.i1.10
pages 1-12

Side Effects of Chemotherapy in Musculoskeletal Oncology

Andreas F. Mavrogenis
First Department of Orthopaedics, Athens University Medical School, Athens, Greece
Panayiotis J. Papagelopoulos
First Department of Orthopaedics, ATTIKON University Hospital, Athens University Medical School, Athens, Greece
Matteo Romantini
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna
Andrea Angelini
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna
Pietro Ruggieri
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna

ABSTRACT

With recent advances in medical and orthopedic oncology, radiation therapy and single- or multiple-agent perioperative chemotherapy are currently applied as an essential part of the multidisciplinary treatment to improve disease-free and overall survival of patients with primary and metastatic bone and soft tissue tumors. However, these treatments have led to unwanted complications. A better understanding of the effects of various antineoplastic agents on bone, soft tissue, and organs may provide the basis for the more efficacious use of antiproliferative drugs when fracture healing or allograft incorporation is required. This knowledge may also provide a rationale for concurrent treatment with drugs that protect against or compensate for adverse effects in osseous repair resulting from chemotherapy.