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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v22.i2.30
pages 127-136

TRAF Family Member-Associated NF-KB Activator (TANK) Gene Polymorphism in Chronic Periodontitis and Peri-implantitis Patients

Mahdi Kadkhodazadeh
Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Reza Amid
Dental Research Center, Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ahmad Reza Ebadian
Dentist, Private practitioner, Aref St., Mashhad, Iran
Elahe Shams
Periodontics Department, Dental School, Shahid Beheshti University of Medical Sciences, Evin, Iran
Mahmood Tamizi
Peridontics department, Dental School, Mashhad University of Medical Sciences, Mashhad, Iran

ABSTRACT

This study sought to determine TANK (rs1921310, rs3820998) gene polymorphism in patients suffering from chronic periodontitis and peri-implantitis among an Iranian population. Materials and Methods: In this cross-sectional study, 77 chronic periodontitis and 40 peri-implantitis patients, along with 89 periodontally healthy subjects, were evaluated. A 5 cc venous blood sample was obtained from subjects. DNA was extracted using Miller's salting-out method and polymorphisms were determined by the use of KBioscience's Competitive Allele-Specific PCR (CASP) genotyping system. Data were analyzed using SPSS version 11.5 software. Differences in allele and genotype frequencies among patients and controls were evaluated with Kruskal-Wallis test. P<0.05 was considered statistically significant. Results: No significant differences were detected between understudy groups in distribution of CC and CA genotypes and alleles when evaluating rs3820998 polymorphism or in distribution of GA and AG genotypes and alleles when assessing rs1921310 polymorphism. Conclusions: Within the limitations of this study, it seems that these two polymorphisms do not play a significant role in pathogenesis of chronic periodontitis or peri-implantitis among the Iranian population. However, we recommend performing similar studies with larger sample sizes among the Iranian population and other communities.