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Journal of Long-Term Effects of Medical Implants

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v22.i2.60
pages 157-163

Comparison of IKKI Gene Polymorphisms (rs1539243 and rs12728136) between Chronic Periodontitis and Peri-implantitis Patients in an Iranian Population (A Cross-Sectional Study)

Mahdi Kadkhodazadeh
Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fatemeh Sodeif
Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mojgan Shavakhi
Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Ahmad Reza Ebadian
Dentist, Private practitioner, Aref St., Mashhad, Iran
Reza Amid
Dental Research Center, Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Siamak Sabour
Department of Clinical Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

ABSTRACT

Aim: In the present study, we sought to assess the correlation of IKKi gene polymorphisms (rs1539243 and rs12728136) with chronic periodontitis and peri-implantitis in an Iranian population for the first time in dentistry. Materials and Methods: This cross-sectional study was conducted on 75 patients with chronic periodontitis, 38 patients with peri-implantitis, and 84 periodontally healthy subjects. Blood samples were taken from all subjects (5 cc venous) and transferred into Falcon tubes containing EDTA. Extracted DNA samples were evaluated with a spectrophotometer (75 ng), transferred into a 96-well plate, and sent to KBioscience Institute in the United Kingdom for analysis. Assessment of IKKi gene polymorphisms was performed at the KBioscience Institute. Data were analyzed using SPSS v19 software. Differences in genotype frequencies and allele among patients and controls were evaluated using the chi-squared test (P<0.05). Results: A significant difference was detected between the peri-implantitis and chronic periodontitis groups in distribution of CC, TC, and TT genotypes in rs1539243 (P<0.05). Statistically significant differences were detected among the three groups in the frequency of T and C alleles for rs1539243 (P=0.03). Conclusions: Within the limitations of the present study, the results showed a significant difference in IKKi gene polymorphism rs1539243 between the peri-implantitis and chronic periodontitis groups. However, such difference was not observed in rs12728136 between the two groups.