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Journal of Long-Term Effects of Medical Implants

Published 4 issues per year

ISSN Print: 1050-6934

ISSN Online: 1940-4379

SJR: 0.184 SNIP: 0.485 CiteScore™:: 1.1 H-Index: 39

Indexed in

A Review on Phosphorylcholine-Coated Stents

Volume 27, Issue 2-4, 2017, pp. 205-219
DOI: 10.1615/JLongTermEffMedImplants.v27.i2-4.80
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ABSTRACT

Stainless steel stents have been developed to perform their primary purpose of providing sufficient physical support to an artery following percutaneous transluminal coronary angioplasty (PTCA) in order to prevent vessel recoil. Early clinical problems, largely caused by subacute thrombosis (SAT), have been significantly reduced with a new generation of antiplatelet agents. Despite improved pharmacological control of SAT in many patients, the potential for stent occlusion remains a life-threatening problem for those with more complex lesions. One strategy for dealing with this is to improve the hemocompatibility of the stent surface with coatings. A phosphorylcholine (PC)-based stent coating has been designed for this purpose; we describe in detail the evaluation of the device, in vitro, through preclinical and early clinical data. We discuss studies that demonstrate that the PC-coated stent may offer some clinical advantage over uncoated counterparts. The extensive experience with this PC-coated device supports its nonthrombogenic nature, excellent acceptance by arterial tissue, and long-term stability in vivo. These characteristics, together with its ability to load and release a variety of therapeutic agents, also make the device a natural choice of platform for future stent- mediated drug delivery for treating restenosis.

CITED BY
  1. Ishihara Kazuhiko, Oda Haruka, Konno Tomohiro, Spontaneously and reversibly forming phospholipid polymer hydrogels as a matrix for cell engineering, Biomaterials, 230, 2020. Crossref

  2. Jariwala Pankaj, Jadhav Karthik, Percutaneous Coronary Intervention of a Diffusely Degenerated Saphenous Vein Graft: A Road Less Taken, EMJ Interventional Cardiology, 2020. Crossref

  3. Istanbullu Omer Burak, Akdogan Gulsen, Influences of Stent Design on In-Stent Restenosis and Major Cardiac Outcomes: A Scoping Review and Meta-Analysis, Cardiovascular Engineering and Technology, 13, 1, 2022. Crossref

  4. Ognard Julien, Abdelrady Mohamed, Gentric Jean-Christophe, Flow Diverter Stents, in Endovascular Surgery of Cerebral Aneurysms, 2022. Crossref

  5. Ishihara Kazuhiko, Biomimetic materials based on zwitterionic polymers toward human-friendly medical devices, Science and Technology of Advanced Materials, 23, 1, 2022. Crossref

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