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Journal of Long-Term Effects of Medical Implants
SJR: 0.133 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v17.i4.40
pages 303-311

Risk of Bacteremia in Patients with Hematological and other Malignancies after Initial Placement of a Central Venous Catheter

Gitte Pedersen
Aalborg Hospital, Denmark
Mette Norgaard
Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
Mathilda Kiiveri
Department of Hematology, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
Henrik Carl Schonheyder
Department of Clinical Microbiology, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
Heidi Larsson
Department of Clinical Epidemiology, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
Erik Stolberg
Department of Anesthesia & Intensive Care, County of North Jutland, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
Petra Witt Andersen
Department of Oncology, Aalborg Hospital, Aarhus University Hospital, DK-9000 Aalborg, Denmark
Henrik Toft Sorensen
Department of Medicine, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee; Department of Clinical Epidemiology, Aarhus University Hospital and Aalborg Hospital, Aarhus, Denmark

ABSTRACT

Background: Widespread use of central venous access devices has made catheter-related bacteremia an important concern. Therefore, we conducted a follow-up study on the risk of bacteremia in Danish patients with hematological or other malignancies after placement of their first central venous access devise. Patients and methods: At a Danish university hospital we identified 357 patients with hematological or other malignancies during a three-year period, 2000-2002. Data on catheter placement and bacteremias were obtained from hospital registries. Clinical data were abstracted from patients' charts. Results: 104 patients had a hematological malignancy (“hem”) and 253 patients had other malignancies (“solid tumor”). A total of 55 patients (34/21) developed bacteremia following catheter placement. After adjustment for age, sex, and comorbidity, the relative risk of bacteremia in the “hem” compared with the “solid tumor” group was 10.8 (95%; CI, 5.8−20.1). In both groups, the central venous catheter was the most frequent focus of infection with no major difference in proportion (50% and 33%, respectively); an unknown focus was also common (50% and 19%, respectively). Conclusion: Patients with hematological malignancies had a 10-fold increased risk of bacteremia compared with other cancer patients and the central venous catheter was not the only important focus.


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