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Journal of Long-Term Effects of Medical Implants
SJR: 0.332 SNIP: 0.491 CiteScore™: 0.89

ISSN Print: 1050-6934
ISSN Online: 1940-4379

Journal of Long-Term Effects of Medical Implants

DOI: 10.1615/JLongTermEffMedImplants.v21.i3.70
pages 233-240

Radiation-Induced Sarcomas

Andreas F. Mavrogenis
First Department of Orthopaedics, National and Kapodistrian University of Athens, School of Medicine, ATTIKON University Hospital, Athens, Greece
Andrea Angelini
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna
Elisa Pala
Istituto Ortopédico Rizzoli, University of Bologna, Bologna, Italy
Teresa Calabro
Istituto Ortopédico Rizzoli, University of Bologna, Bologna, Italy
Giuseppe Bianchi
Istituto Ortopédico Rizzoli, University of Bologna, Bologna, Italy
Roberto Casadei
Istituto Ortopédico Rizzoli, University of Bologna, Bologna, Italy
Pietro Ruggieri
Istituto Ortopedico Rizzoli, Department of Orthopaedics, University of Bologna, Bologna

ABSTRACT

Radiation-induced sarcomas are rare, high-grade sarcomas that may arise within the radiation volume at a mean latency period of 3-55 years after radiation therapy, doses of which range from 45 to 60 Gy. Radiation-induced osteosarcomas, fibrosarcomas, and malignant fibrous histiocytomas are the most common. Extensive surgery with microscopically negative-margin resection, or amputation is recommended for improved survival. Adjuvant radiation therapy and chemotherapy have not been shown to improve survival rates significantly. The prognosis is poor.