Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i4.10
pages 275-303

Crossregulation Between Th1 and Th2 Cells

Penelope A. Morel
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA; Co-senior authors
Timothy B. Oriss
Department of Medicine, University of Pittsburgh and the University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213


Th1 and Th2 subsets have been characterized on the basis of the cytokines they secrete and the immune functions they mediate. Th1 cells secrete IL-2, IFN-γ, and lymphotoxin and are important in the cell-mediated response; Th2 cells secrete IL-4, IL-5, IL-10, and IL-13 and are important in the control of macrophage function and in the stimulation of particular immunoglobulin isotypes. Cytokines secreted by Thl and Th2 cells regulate the growth and differentiation of Thl and Th2 cells in both positive and negative ways; this has been termed crossregulation. Much work has concentrated on the factors important in the differentiation of these Th subsets, and it has been established that Th cells become committed to a Thl or Th2 phenotype within 48 hrs of antigenic stimulation. During the differentiation process irreversible changes in the expression and function of cytokine receptors occur that provide an explanation for the observed crossregulatory features of Thl and Th2 cells. In this review we summarize the crossregulation between Thl and Th2 cells in terms of the changes in cytokine receptor expression and function that occur during differentiation.

Articles with similar content:

Differentiation of NK1 and NK2 Cells
Critical Reviews™ in Immunology, Vol.25, 2005, issue 5
Motoko Y. Kimura, Toshinori Nakayama
Mechanism of Activation-Induced Cell Death of T Cells and Regulation of FasL Expression
Critical Reviews™ in Immunology, Vol.34, 2014, issue 4
Akiko Yamada, Yasusei Kudo, Yoshio Hayashi, Naozumi Ishimaru, Rieko Arakaki
MHC Transfer from APC to T Cells Following Antigen Recognition
Critical Reviews™ in Immunology, Vol.26, 2006, issue 1
Scott A. Wetzel, David C. Parker
Structure and Function of the CD7 Molecule
Critical Reviews™ in Immunology, Vol.19, 1999, issue 4
Russell E. Kaufman, Barton F. Haynes, Gregory D. Sempowski, David M. Lee
Role of IL-21 and IL-21 Receptor on B Cells in HIV Infection
Critical Reviews™ in Immunology, Vol.32, 2012, issue 2
Suresh Pallikkuth, Savita Pahwa, Anita Parmigiani