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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v27.i2.20
pages 141-151

Novel Functions of B Cells

Marilia Cascalho
Transplantation Biology and the Departments of Immunology, Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN
Jeffrey L. Platt
Transplantation Biology and the Departments of Immunology, Surgery, and Pediatrics, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN

ABSTRACT

T cells clearly help B cells to produce antibodies and acquire memory. Recently, B cells were found to support some T-cell responses through antigen presentation, and perhaps more importantly, through the generation of diverse T cells and lymphoid organogenesis. These new findings show that the development and function of T cells depend on B cells independently of specific antibody production.