Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 0.657 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i3.30
12 pages

The Role of Dectin-1 in Antifungal Immunity

Jurgen Herre
Sir William Dunn School of Pathology, University of Oxford, UK
Janet A. Willment
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Siamon Gordon
Sir William Dunn School of Pathology, University of Oxford, UK
Gordon D. Brown
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa

ABSTRACT

β-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role. Dectin-1 is expressed on phagocytic cells, including macrophages and neutrophils, and mediates both the internalization and cellular responses to β-glucan, through unique mechanisms. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule, although its function in these responses is less clear. This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding.


Articles with similar content:

Innate Immunity Induced by Fungal β-Glucans via Dectin-1 Signaling Pathway
International Journal of Medicinal Mushrooms, Vol.16, 2014, issue 1
Ha Won Kim, Dong Hee Lee
Understanding How Lipopolysaccharide Impacts CD4 T-Cell Immunity
Critical Reviews™ in Immunology, Vol.28, 2008, issue 4
Anthony T. Vella, Jeremy P. McAleer
Host Immune Responses to the Intracellular Bacteria Brucella: Does the Bacteria Instruct the Host to Facilitate Chronic Infection?
Critical Reviews™ in Immunology, Vol.26, 2006, issue 5
Cynthia L. Baldwin, Radhika Goenka
Important Biology Events and Pathways in Brucella Infection and Implications for Novel Antibiotic Drug Targets
Critical Reviews™ in Eukaryotic Gene Expression, Vol.23, 2013, issue 1
Guangjun Gao, Jie Xu
Signal Integration Following Toll-like Receptor Triggering
Critical Reviews™ in Immunology, Vol.22, 2002, issue 3
Alexander Dalpke, Klaus Heeg