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Critical Reviews™ in Immunology
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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i3.30
12 pages

The Role of Dectin-1 in Antifungal Immunity

Jurgen Herre
Sir William Dunn School of Pathology, University of Oxford, UK
Janet A. Willment
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa
Siamon Gordon
Sir William Dunn School of Pathology, University of Oxford, UK
Gordon D. Brown
Institute of Infectious Disease and Molecular Medicine, University of Cape Town, South Africa

ABSTRACT

β-Glucans are structural components of fungal cell walls, which have a stimulatory effect on the immune system. Although a number of receptors for these carbohydrates have been proposed, the recently identified C-type lectin-like receptor, Dectin-1, appears to play a central role. Dectin-1 is expressed on phagocytic cells, including macrophages and neutrophils, and mediates both the internalization and cellular responses to β-glucan, through unique mechanisms. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule, although its function in these responses is less clear. This review will highlight the current knowledge of Dectin-1 and its potential role in antifungal immunity, as well as deficiencies in our understanding.


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