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Critical Reviews™ in Immunology

Impact factor: 3.698

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v31.i1.10
pages 1-13

Myeloid Hypoxia-Inducible Factors in Inflammatory Diseases

Julian Aragones
Servicio de Inmunología, Hospital Universitario de La Princesa
Ainara Elorza
Servicio de Inmunología, Hospital Universitario de La Princesa
Barbara Acosta-Iborra
Servicio de Inmunología, Hospital Universitario de La Princesa
Manuel O. Landazuri
Servicio de Inmunología, Hospital Universitario de La Princesa

ABSTRACT

Hypoxia inducible factors (HIF1 and HIF2) have emerged as central regulators of the activity of myeloid cells at inflammatory sites where O2 is frequently limited. Novel insights in the field have revealed that the expression of HIFs by myeloid cells is not exclusively induced by hypoxia but also in response to central inflammatory mediators independently of O2 shortage. This has substantially elevated the biological significance of HIFs in the context of inflammatory diseases. As a consequence, the loss of HIF1 or HIF2 in myeloid cells specifically compro-mises some of the processes driven by myeloid cells, such as bactericidal activity and myeloid invasion, as well as inflammation-associated detrimental consequences.