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Critical Reviews™ in Immunology
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ISSN Print: 1040-8401
ISSN Online: 2162-6472

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Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i4.10
10 pages

Negative Regulation of T-Cell Function by PD-1

Yuan yuan Zha
University of Chicago, Department of Pathology and Department of Medicine, Section of Hematology/ Oncology, Chicago, IL 60637
Christian Blank
University of Chicago, Department of Pathology and Department of Medicine, Section of Hematology/ Oncology, Chicago, IL 60637
Thomas F. Gajewski
University of Chicago, Department of Pathology and Department of Medicine, Section of Hematology/ Oncology, Chicago, IL 60637

ABSTRACT

PD-1 is a receptor inducibly expressed on CD4+ and CD8+ T cells Mowing activation. PD-1-deficient mice develop signs of autoimmunity, suggesting a negative regulatory role for PD-1 in dampening lymphocyte responses. The expression of one ligand for PD-1, designated PD-L1 or B7-H1, on tumor cells of a variety of histologies has suggested a potential mechanism for tumor escape from immune destruction. This review summarizes data regarding PD-1 and related negative regulatory receptors, focusing on implications for potentiating antitumor immunity in vivo.


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