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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v25.i4.50
pages 331-342

Function of Marginal Zone B Cells in Antiviral B-Cell Responses

Dominique Gatto
Cytos Biotechnology AG, Wagistrasse 25, CH-8952 Zurich-Schlieren, Switzerland
Martin F. Bachmann
Cytos Biotechnology AG, Wagistrasse 25, CH-8952 Zurich-Schlieren, Switzerland

ABSTRACT

B cells of the marginal zone (MZ) compartment are poised to combat infectious threats reaching the bloodstream. They owe this ability to their unique location at the ports of entry of blood-borne pathogens as well as to their distinct functional properties. MZ B cells respond to antigen encounters with rapid activation, local antibody secretion, and isotype switching. In addition, they are involved in antigen trapping, transport, and presentation. Herein, we review the current data on the functional characteristics that enable the MZ B-cell population to act as an efficient first line of defense against systemic infections.