Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.404 5-Year IF: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v30.i3.60
pages 291-298

Modeling the Viral Dynamics of Influenza A Virus Infection

Amber M. Smith
Department of Mathematics, University of Utah, Salt Lake City, Utah; Department of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico
Ruy M. Ribeiro
Department of Theoretical Biology and Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico


Influenza virus causes an acute, mostly self-limited, infection of the upper respiratory tract. Yearly epidemics of influenza infect up to 20% of the population, and in the US cause an average of 36,000 deaths every year. Because influenza is a short-term infection lasting 4 to 7 d in most cases, studying the dynamics of the virus and the immune response in vivo is difficult. Here we review the most recent attempts at mathematical modeling of influenza dynamics within the host to better understand the kinetics of the virus and associated immune responses. These models have been developed based on very successful kinetic studies of chronic infections, such as human immunodeficiency and hepatitis C viruses. We briefly review the approach taken for these infections before discussing the results obtained in the case of influenza. The dynamics of the latter have been studied both in vitro and in vivo. It was shown that the virus turnover is very fast, which helps to explain the accumulation of diversity. Moreover, initial attempts have been made at modeling the immune response to influenza, but these are still incipient and further studies, both experimental and theoretical, are needed to better elucidate the interplay of the virus and the immune response.

Articles with similar content:

Immunological Mechanisms Involved In Experimental Peptide Immunotherapy of T-Cell-Mediated Diseases
Critical Reviews™ in Immunology, Vol.20, 2000, issue 6
Marca H. M. Wauben
Differences in Innate Immune Response between Man and Mouse
Critical Reviews™ in Immunology, Vol.34, 2014, issue 5
Denise Schlorke, Josefin Zschaler, Juergen Arnhold
The Role of the immunological Synapse Formed by Cytotoxic Lymphocytes in Immunodeficiency and Anti-Tumor immunity
Critical Reviews™ in Immunology, Vol.35, 2015, issue 4
Amelia J. Brennan, Conor J. Kearney, Phillip K. Darcy, Jane Oliaro
The Ambivalent Nature of T-Cell Infiltration in the Central Nervous System of Patients with Multiple Sclerosis
Critical Reviews™ in Immunology, Vol.27, 2007, issue 1
Jerome J. A. Hendriks, Joris Vanderlocht, Piet Stinissen, Niels Hellings
Antibacterial and Antiviral Value of the Genus Ganoderma P. Karst. Species (Aphyllophoromycetideae): A Review
International Journal of Medicinal Mushrooms, Vol.5, 2003, issue 3
Yihuai Gao, Min Huang, Anlong Xu, Shufeng Zhou