Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Toll-Like Receptor Family in Domestic Animal Species
ABSTRACT
Toll-like receptors (TLRs) arc a family of evolutionarily conserved, integral membrane glycoproteins that play a key role in innate immunity through the early sensing of pathogens and the initiation of appropriate responses. Each TLR receptor recognizes conserved motifs in macromolecular components from viruses and bacteria; the expression of the TLRs in cells and tissues therefore provide specific responses to pathogenic challenges. TLR activation addresses and reinforces both arms of the immune response (innate and adaptive), leading to prompt and specific activities toward pathogens. Although best studied in mouse and human genomes, orthologous TLRs have been identified in other vertebrates, including fish. Because of their early function of controlling immunity in animal species, TLR genes can be considered traits conferring disease resistance and should be considered suitable targets in the development of innovative immunotherapeutic. In the present review, the current knowledge on TLR receptors in domestic animal species is summarized and discussed from the point of view of the host-pathogen interaction.
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Casas E., Hessman B. E., Keele J. W., Ridpath J. F., A genome-wide association study for the incidence of persistent bovine viral diarrhea virus infection in cattle, Animal Genetics, 46, 1, 2015. Crossref
-
Jungi Thomas W., Farhat Katja, Burgener Iwan A., Werling Dirk, Toll-like receptors in domestic animals, Cell and Tissue Research, 343, 1, 2011. Crossref
-
Vaure Céline, Liu Yuanqing, A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species, Frontiers in Immunology, 5, 2014. Crossref
-
Huber Stephanie, Roosje Petra J., Janda Jozef, Schnyder Michaela, Jungi Thomas W., Bertoni Giuseppe, Zurbriggen Andreas, Burgener Iwan A., Characterization of antibodies specific for canine TLR4, 5 and 9 by ELISA, Western blotting and immunohistochemistry, Veterinary Immunology and Immunopathology, 144, 3-4, 2011. Crossref
-
Lewis D.H., Chan D.L., Pinheiro D., Armitage-Chan E., Garden O.A., The Immunopathology of Sepsis: Pathogen Recognition, Systemic Inflammation, the Compensatory Anti-Inflammatory Response, and Regulatory T Cells, Journal of Veterinary Internal Medicine, 26, 3, 2012. Crossref
-
Farias María Victoria Nieto, Lendez Pamela Anahí, Marin Maia, Quintana Silvina, Martínez-Cuesta Lucía, Ceriani María Carolina, Dolcini Guillermina Laura, Toll-like receptors, IFN-γ and IL-12 expression in bovine leukemia virus-infected animals with low or high proviral load, Research in Veterinary Science, 107, 2016. Crossref
-
Foroutan Masoud, Zaki Leila, Ghaffarifar Fatemeh, Recent progress in microneme-based vaccines development againstToxoplasma gondii, Clinical and Experimental Vaccine Research, 7, 2, 2018. Crossref
-
Fan Timothy M., Selting Kimberly A., Exploring the Potential Utility of Pet Dogs With Cancer for Studying Radiation-Induced Immunogenic Cell Death Strategies, Frontiers in Oncology, 8, 2019. Crossref
-
Vail David M., Thamm Douglas H., Spontaneous Companion Animal (Pet) Cancers, in Tumor Models in Cancer Research, 2011. Crossref
-
Katwal Pratik, Thomas Milton, Uprety Tirth, Hildreth Michael B., Kaushik Radhey S., Development and biochemical and immunological characterization of early passage and immortalized bovine intestinal epithelial cell lines from the ileum of a young calf, Cytotechnology, 71, 1, 2019. Crossref
-
Menchetti Laura, Barbato Olimpia, Sforna Monica, Vigo Daniele, Mattioli Simona, Curone Giulio, Tecilla Marco, Riva Federica, Brecchia Gabriele, Effects of Diets Enriched in Linseed and Fish Oil on the Expression Pattern of Toll-Like Receptors 4 and Proinflammatory Cytokines on Gonadal Axis and Reproductive Organs in Rabbit Buck, Oxidative Medicine and Cellular Longevity, 2020, 2020. Crossref
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-
Casas Eduardo, Ma Hao, Lippolis John D., Expression of Viral microRNAs in Serum and White Blood Cells of Cows Exposed to Bovine Leukemia Virus, Frontiers in Veterinary Science, 7, 2020. Crossref
-
Rossi Luciana, Turin Lauretta, Alborali Giovanni Loris, Demartini Eugenio, Filipe Joel Fernando Soares, Riva Federica, Riccaboni Pietro, Scanziani Eugenio, Trevisi Paolo, Dall’Ara Paola, Dell’Anno Matteo, Baldi Antonella, Translational Approach to Induce and Evaluate Verocytotoxic E. coli O138 Based Disease in Piglets, Animals, 11, 8, 2021. Crossref
-
Liao Zhiwei, Su Jianguo, Progresses on three pattern recognition receptor families (TLRs, RLRs and NLRs) in teleost, Developmental & Comparative Immunology, 122, 2021. Crossref
-
Capozza Paolo, Pratelli Annamaria, Camero Michele, Lanave Gianvito, Greco Grazia, Pellegrini Francesco, Tempesta Maria, Feline Coronavirus and Alpha-Herpesvirus Infections: Innate Immune Response and Immune Escape Mechanisms, Animals, 11, 12, 2021. Crossref
-
Liao Zhiwei, Yang Chunrong, Jiang Rui, Zhu Wentao, Zhang Yongan, Su Jianguo, Cyprinid‐specific duplicated membrane TLR5 senses dsRNA as functional homodimeric receptors, EMBO reports, 23, 8, 2022. Crossref