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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v24.i6.40
16 pages

Development and Function of the Splenic Marginal Zone

Reina E. Mebius
VU Medical Center, Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands
Martijn A. Nolte
Immunobiology Laboratory, Cancer Research UK, Lincoln's Inn Fields Laboratories, London, United Kingdom
Georg Kraal
VU Medical Center, Department of Molecular Cell Biology and Immunology, Amsterdam, The Netherlands

ABSTRACT

The marginal zone of the spleen is a crucial region where blood-borne pathogens are sequestered by macrophages with unique arrays of scavenger molecules. In addition, a special population of B cells, which is capable of rapid activation, resides in this region. Marginal zone B cells and macrophages together form an efficient interplay between innate and adaptive immunity. The developmental pathways that lead to the formation of the marginal zone are described, and the function of the marginal zone is discussed in relation to the function of the spleen as the major blood-filtering organ of the body.


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