Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Mechanisms and Mediators of Pulmonary Fibrosis

Volume 25, Issue 6, 2005, pp. 429-464
DOI: 10.1615/CritRevImmunol.v25.i6.10
Get accessGet access

ABSTRACT

The mechanisms of pulmonary fibrosis are complex, and several hypotheses have been put forward to explain how fibrosis develops. It was long thought that inflammation was a key event in the process; however, this has recently been challenged. The inflammation hypothesis has led to the description of numerous inflammatory and profibrotic mediators in the pathogenesis of fibrosis. Inhibition of inflammation can attenuate fibrosis in animal models but is less successful in humans. More recently, an important role for epithelial injury, circulating mesenchymal precursor cells, epithelial-to-mesenchymal transition, and vascular remodeling have been described in various models of fibrosis. Many of the classic inflammatory and profibrotic mediators are important in these processes, as well. The development of effective therapies will require the understanding of the complex interplay of the various mediators and the mechanisms of remodeling.

CITED BY
  1. Jin Gong Yong, Bok Se Mi, Han Young Min, Chung Myung Ja, Yoon Kwon-Ha, Kim So Ri, Lee Yong Chul, Effectiveness of rosiglitazone on bleomycin-induced lung fibrosis: Assessed by micro-computed tomography and pathologic scores, European Journal of Radiology, 81, 8, 2012. Crossref

  2. Omary M. Bishr, Lugea Aurelia, Lowe Anson W., Pandol Stephen J., The pancreatic stellate cell: a star on the rise in pancreatic diseases, Journal of Clinical Investigation, 117, 1, 2007. Crossref

  3. PAN Jin Bing, HOU Yu Hong, ZHANG Guo Jun, Rolipram attenuates bleomycin A5-induced pulmonary fibrosis in rats, Respirology, 14, 7, 2009. Crossref

  4. Fix Charity, Bingham Kellie, Carver Wayne, Effects of interleukin-18 on cardiac fibroblast function and gene expression, Cytokine, 53, 1, 2011. Crossref

  5. Mori Ryoichi, Shaw Tanya J., Martin Paul, Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring, Journal of Experimental Medicine, 205, 1, 2008. Crossref

  6. Molina-Molina María, Pereda Javier, Xaubet Antoni, Experimental Models for the Study of Pulmonary Fibrosis: Current Usefulness and Future Promise, Archivos de Bronconeumología ((English Edition)), 43, 9, 2007. Crossref

  7. Kolonin Mikhail G., Evans Kurt W., Mani Sendurai A., Gomer Richard H., Alternative origins of stroma in normal organs and disease, Stem Cell Research, 8, 2, 2012. Crossref

  8. Molina-Molina María, Pereda Javier, Xaubet Antoni, Modelos experimentales para el estudio de la fibrosis pulmonar: utilidad práctica actual y futura, Archivos de Bronconeumología, 43, 9, 2007. Crossref

  9. Mangoni Monica, Sottili Mariangela, Gerini Chiara, Bonomo Pierluigi, Bottoncetti Anna, Castiglione Francesca, Franzese Ciro, Cassani Sara, Greto Daniela, Masoni Tatiana, Meattini Icro, Pallotta Stefania, Passeri Alessandro, Pupi Alberto, Vanzi Eleonora, Biti Giampaolo, Livi Lorenzo, A PPAR-gamma agonist attenuates pulmonary injury induced by irradiation in a murine model, Lung Cancer, 90, 3, 2015. Crossref

  10. Caldwell Charles C., Chen Yi, Goetzmann Holly S., Hao Yonghua, Borchers Michael T., Hassett Daniel J., Young Lisa R., Mavrodi Dmitri, Thomashow Linda, Lau Gee W., Pseudomonas aeruginosa Exotoxin Pyocyanin Causes Cystic Fibrosis Airway Pathogenesis, The American Journal of Pathology, 175, 6, 2009. Crossref

  11. Yao Rong, He Yarong, Zeng Zhi, Liang Zongan, Cao Yu, Protective effect of adiponectin on paraquat-induced pulmonary fibrosis in mice, Molecular & Cellular Toxicology, 11, 2, 2015. Crossref

  12. Hagiwara Satoshi, Iwasaka Hideo, Matsumoto Shigekiyo, Noguchi Takayuki, Antisense oligonucleotide inhibition of Heat Shock Protein (HSP) 47 improves bleomycin-induced pulmonary fibrosis in rats, Respiratory Research, 8, 1, 2007. Crossref

  13. You Jia, Wang Jintao, Xie Linshen, Zhu Chengwen, Xiong Jingyuan, D-4F, an apolipoprotein A-I mimetic, inhibits TGF-β1 induced epithelial-mesenchymal transition in human alveolar epithelial cell, Experimental and Toxicologic Pathology, 68, 9, 2016. Crossref

  14. Song Cheng, He Lujuan, Zhang Jin, Ma Hong, Yuan Xiangning, Hu Gaoyun, Tao Lijian, Zhang Jian, Meng Jie, Fluorofenidone attenuates pulmonary inflammation and fibrosis via inhibiting the activation of NALP 3 inflammasome and IL ‐1β/ IL ‐1R1/MyD88/ NF ‐κB pathway , Journal of Cellular and Molecular Medicine, 20, 11, 2016. Crossref

  15. Moore Bethany B., Hogaboam Cory M., Murine models of pulmonary fibrosis, American Journal of Physiology-Lung Cellular and Molecular Physiology, 294, 2, 2008. Crossref

  16. Lim Jin Hong, Park Joon Seong, Yoon Dong Sup, Preoperative fecal elastase-1 is a useful prognostic marker following curative resection of pancreatic cancer, HPB, 19, 5, 2017. Crossref

  17. Saito Yukihiro, Development of Gene Therapy for Lymphedema, The Japanese Journal of Phlebology, 28, 3, 2017. Crossref

  18. Milam Jami E., Keshamouni Venkateshwar G., Phan Sem H., Hu Biao, Gangireddy Srinivasa R., Hogaboam Cory M., Standiford Theodore J., Thannickal Victor J., Reddy Raju C., PPAR-γ agonists inhibit profibrotic phenotypes in human lung fibroblasts and bleomycin-induced pulmonary fibrosis, American Journal of Physiology-Lung Cellular and Molecular Physiology, 294, 5, 2008. Crossref

  19. Smith Monica R., Gangireddy Srinivasa R., Narala Venkata R., Hogaboam Cory M., Standiford Theodore J., Christensen Paul J., Kondapi Anand K., Reddy Raju C., Curcumin inhibits fibrosis-related effects in IPF fibroblasts and in mice following bleomycin-induced lung injury, American Journal of Physiology-Lung Cellular and Molecular Physiology, 298, 5, 2010. Crossref

  20. Zhan Tian-Wei, Tian Yu-Xin, Wang Qi, Wu Zi-Xiang, Zhang Wei-Ping, Lu Yun-Bi, Wu Ming, Cangrelor alleviates pulmonary fibrosis by inhibiting GPR17-mediated inflammation in mice, International Immunopharmacology, 62, 2018. Crossref

  21. Xue Ran, Jia Kai, Wang Jianxin, Yang Lixin, Wang Yanbin, Gao Lingyun, Hao Jianyu, A Rising Star in Pancreatic Diseases: Pancreatic Stellate Cells, Frontiers in Physiology, 9, 2018. Crossref

  22. Ireland Lucy V., Mielgo Ainhoa, Macrophages and Fibroblasts, Key Players in Cancer Chemoresistance, Frontiers in Cell and Developmental Biology, 6, 2018. Crossref

  23. Matsuzawa Yasuo, Kawashima Tatsuo, Yamazaki Risa, Yamaura Erika, Makiyama Tomohiko, Fujino Hiromichi, Murayama Toshihiko, Inhibitory effects of clinical reagents having anti-oxidative activity on transforming growth factor-.BETA.1-induced expression of .ALPHA.-smooth muscle actin in human fetal lung fibroblasts, The Journal of Toxicological Sciences, 36, 6, 2011. Crossref

  24. Ohbayashi Masayuki, Suzuki Masanori, Yashiro Yoshiki, Fukuwaka Sayaka, Yasuda Masako, Kohyama Noriko, Kobayashi Yasuna, Yamamoto Toshinori, Induction of pulmonary fibrosis by methotrexate treatment in mice lung in vivo and in vitro, The Journal of Toxicological Sciences, 35, 5, 2010. Crossref

  25. Ryffel Bernhard, Togbe Dieudonnée, Couillin Isabelle, Inflammasome and Lung Pathologies, in The Inflammasomes, 2011. Crossref

  26. Venkatesan Narayanan, Punithavathi Durairaj, Babu Mary, PROTECTION FROM ACUTE AND CHRONIC LUNG DISEASES BY CURCUMIN, in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, 595, 2007. Crossref

  27. Simonian Philip L., Roark Christina L., Diaz del Valle Fernando, Palmer Brent E., Douglas Ivor S., Ikuta Koichi, Born Willi K., O’Brien Rebecca L., Fontenot Andrew P., Regulatory Role of γδ T Cells in the Recruitment of CD4+and CD8+T Cells to Lung and Subsequent Pulmonary Fibrosis, The Journal of Immunology, 177, 7, 2006. Crossref

  28. Gasse Pamela, Mary Caroline, Guenon Isabelle, Noulin Nicolas, Charron Sabine, Schnyder-Candrian Silvia, Schnyder Bruno, Akira Shizuo, Quesniaux Valérie F.J., Lagente Vincent, Ryffel Bernhard, Couillin Isabelle, IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice, Journal of Clinical Investigation, 2007. Crossref

  29. Farran Batoul, Nagaraju Ganji Purnachandra, The dynamic interactions between the stroma, pancreatic stellate cells and pancreatic tumor development: Novel therapeutic targets, Cytokine & Growth Factor Reviews, 48, 2019. Crossref

  30. Zhan Tianwei, Wei Taofeng, Dong Lingjun, Wang Qi, Wu Zixiang, Yan Qihang, Zhang Weiping, Lu Yunbi, Wu Ming, Cangrelor alleviates bleomycin-induced pulmonary fibrosis by inhibiting platelet activation in mice, Molecular Immunology, 120, 2020. Crossref

  31. Jiang Linxia, Wang Jianhong, Ju Jiarui, Dai Jundong, Salvianolic acid B and sodium tanshinone II A sulfonate prevent pulmonary fibrosis through anti-inflammatory and anti-fibrotic process, European Journal of Pharmacology, 883, 2020. Crossref

  32. Kang Yun Pyo, Lee Sae Bom, Lee Ji-min, Kim Hyung Min, Hong Ji Yeon, Lee Won Jun, Choi Chang Woo, Shin Hwa Kyun, Kim Do-Jin, Koh Eun Suk, Park Choon-Sik, Kwon Sung Won, Park Sung-Woo, Metabolic Profiling Regarding Pathogenesis of Idiopathic Pulmonary Fibrosis, Journal of Proteome Research, 15, 5, 2016. Crossref

  33. Card Jeffrey W., Voltz James W., Carey Michelle A., Bradbury J. Alyce, DeGraff Laura M., Lih Fred B., Bonner James C., Morgan Daniel L., Flake Gordon P., Zeldin Darryl C., Cyclooxygenase-2 Deficiency Exacerbates Bleomycin-Induced Lung Dysfunction but Not Fibrosis, American Journal of Respiratory Cell and Molecular Biology, 37, 3, 2007. Crossref

  34. Bantsimba-Malanda Claudie, Marchal-Sommé Joëlle, Goven Delphine, Freynet Olivia, Michel Laurence, Crestani Bruno, Soler Paul, A Role for Dendritic Cells in Bleomycin-induced Pulmonary Fibrosis in Mice?, American Journal of Respiratory and Critical Care Medicine, 182, 3, 2010. Crossref

  35. Kim Tae Hoon, Lee Yoo Hoon, Kim Kyung Hun, Lee Shin Hwa, Cha Ji Yeon, Shin Eun Kyoung, Jung Seok, Jang An Soo, Park Sung Woo, Uh Soo Taek, Kim Young Hoon, Park Jai Soung, Sin Hwa Gyoun, Youm Wook, Koh Eun Suk, Cho Sun Young, Paik Young Ki, Rhim Tai Youn, Park Choon Sik, Role of Lung Apolipoprotein A-I in Idiopathic Pulmonary Fibrosis, American Journal of Respiratory and Critical Care Medicine, 182, 5, 2010. Crossref

  36. Pulichino Anne-Marie, Wang I-Ming, Caron Alexandre, Mortimer James, Auger Anick, Boie Yves, Elias Jack A., Kartono Aileen, Xu Lijing, Menetski Joseph, Sayegh Camil E., Identification of Transforming Growth Factor β1–Driven Genetic Programs of Acute Lung Fibrosis, American Journal of Respiratory Cell and Molecular Biology, 39, 3, 2008. Crossref

  37. Marchal-Sommé Joëlle, Uzunhan Yurdagul, Marchand-Adam Sylvain, Kambouchner Marianne, Valeyre Dominique, Crestani Bruno, Soler Paul, Dendritic Cells Accumulate in Human Fibrotic Interstitial Lung Disease, American Journal of Respiratory and Critical Care Medicine, 176, 10, 2007. Crossref

  38. Venkatesan Narayanan, Tsuchiya Kimitake, Kolb Martin, Farkas Laszlo, Bourhim Mustapha, Ouzzine Mohamed, Ludwig Mara S., Glycosyltransferases and Glycosaminoglycans in Bleomycin and Transforming Growth Factor-β1–Induced Pulmonary Fibrosis, American Journal of Respiratory Cell and Molecular Biology, 50, 3, 2014. Crossref

  39. Daniels Craig E., Lasky Joseph A., Limper Andrew H., Mieras Kathleen, Gabor Edith, Schroeder Darrell R., Imatinib Treatment for Idiopathic Pulmonary Fibrosis, American Journal of Respiratory and Critical Care Medicine, 181, 6, 2010. Crossref

Forthcoming Articles

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain