Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
CD4+ T Cell Activation During the Newborn Period: Barriers Against and Pathways Toward Th1 Immunity
ABSTRACT
During the period of transition from intrauterine to extrauterine life, the neonatal immune system must learn to rapidly identify pathogens while balancing pro-inflammatory, antimicrobial responses with immune regulation that allows for resolution of inflammation and limits responses to commensal organisms and benign environmental antigens. However, the naive immune system of neonates is presented with several barriers that limit robust proinflammatory immune responses. Specifically, epigenetic modifications to neonatal naive CD4+ T cells, heightened neonatal regulatory T cell frequency and function, and limitations in the co-stimulatory potential of neonatal antigen presenting cells restrict development of CD4+ T cells with a T-helper 1 type functional profile. This restriction likely contributes to the increased risk of severe infection observed during early life. New research, however, suggests that neonates are capable of utilizing unique compensatory mechanisms to circumvent these restrictions and generate T-helper 1 type immunity under some circumstances. Understanding how to manipulate the immune responses of young infants to optimize development of T-helper 1 type immunity is key to the development of immune-based treatments and prevention strategies for severe infections in this vulnerable population.
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Verhoeven David, Immunometabolism and innate immunity in the context of immunological maturation and respiratory pathogens in young children, Journal of Leukocyte Biology, 106, 2, 2019. Crossref
-
Fedoseenko Marina V., Petrova Veronika A., Namazova-Baranova Leyla S., Prevalence of Allergic Diseases in Children Vaccinated Against Tuberculosis and Hepatitis B in the Early Neonatal Period: Literature Review, Pediatric pharmacology, 18, 5, 2021. Crossref
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Yu Hong-Ren, Hsu Te-Yao, Tsai Ching-Chang, Huang Hsin-Chun, Cheng Hsin-Hsin, Lai Yun-Ju, Lin Yu-Ju, Chen Chih-Cheng, Li Sung-Chou, Yang Kuender, The Functional DNA Methylation Signatures Relevant to Altered Immune Response of Neonatal T Cells with l-Arginine Supplementation, Nutrients, 13, 8, 2021. Crossref
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Dietert Rodney R., Coleman Margaret E., North D. Warner, Stephenson Michele M., Nourishing the Human Holobiont to Reduce the Risk of Non-Communicable Diseases: A Cow’s Milk Evidence Map Example, Applied Microbiology, 2, 1, 2021. Crossref
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Zhang Qianqian, Zhao Jiuru, Ni Meng, Shen Qianwen, Zhou Wenhao, Liu Zhiwei, Vitamin D3 reverses the transcriptional profile of offspring CD4+ T lymphocytes exposed to intrauterine inflammation, The Journal of Steroid Biochemistry and Molecular Biology, 221, 2022. Crossref