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Critical Reviews™ in Immunology

Impact factor: 3.857

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v28.i1.30
pages 45-60

Pinning Down Signaling in the Immune System: The Role of the Peptidyl-Prolyl Isomerase Pin1 in Immune Cell Function

Stephane Esnault
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine and UW-Madison School of Medicine and Public Health
Zong-Jian Shen
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine and UW-Madison School of Medicine and Public Health
James S. Malter
Waisman Center for Developmental Disabilities, Department of Pathology and Laboratory Medicine and UW-Madison School of Medicine and Public Health

ABSTRACT

The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle control and neuropathologies. There is now growing evidence that Pin1 plays an important role in the immune system and does so differentially from the related PPIases, cyclophilinA and FKBP. This review describes how Pin1 modulates cytokine expression by activated T cells and eosinophils and participates in T-cell and eosinophil apoptotic decisions both in vitro and in vivo. We highlight several possible immunologic diseases, including asthma, as well as organ transplant rejection, where anti-Pin1 therapeutics maybe of value.