Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Neuronal Derivative Mediators That Regulate Cutaneous Inflammations

Volume 32, Issue 4, 2012, pp. 307-320
DOI: 10.1615/CritRevImmunol.v32.i4.20
Get accessGet access

ABSTRACT

Allergic diseases accompanied by skin inflammation are intricately regulated by several mediators. Among these molecules, neurotransmitters are known to affect several immune cells such as T cells, B cells, dendritic cells, and mast cells. Neurotransmitters are released from nerve endings, and most of them work through specific G-protein coupled receptors. In this review, we discuss the interactions of representative neurotransmitters, calcitonin gene-related peptide (CGRP), substance P (SP), neuropeptide Y (NPY), vasoactive intestinal peptide (VIP)/pituitary adenylate cyclase-activating polypeptide (PACAP), and prostaglandins (PGs), as well as their receptor signaling systems such as the cAMP/protein kinase A (PKA) pathway, phospholipase C (PLC) activation, and calcium ion channel activation, in cutaneous immunity.
Although many studies have proposed that these neurotransmitters play several roles in mouse contact hypersensitivity (CHS) models, human allergic contact dermatitis (ACD), and atopic dermatitis (AD), their physiological effects are controversial due to the diverse and complex mechanisms of skin inflammation. Both Th1- and Th2-mediated skin inflammation are well known, and neurotransmitters affect the kinds of inflammatory cells and subsequent immune reactions in them. In addition, the characteristics of antigen-presenting cells are also different in Th1- or Th2-mediated immune responses. Therefore, we take particular note of the type of skin inflammation, Th1- or Th2-mediated, and review the physiological roles of the neurotransmitters in skin inflammation.

CITED BY
  1. Sugimoto Atsushi, Kawakami Ryoji, Mikami Norihisa, Transcription Factors Downstream of IL-4 and TGF-β Signals: Analysis by Quantitative PCR, Western Blot, and Flow Cytometry, in Th9 Cells, 1585, 2017. Crossref

  2. Verma Alok K., Manohar Murli, Upparahalli Venkateshaiah Sathisha, Mishra Anil, Neuroendocrine cells derived chemokine vasoactive intestinal polypeptide (VIP) in allergic diseases, Cytokine & Growth Factor Reviews, 38, 2017. Crossref

  3. Schebesch Karl-Michael, Brawanski Alexander, Bele Sylvia, Schödel Petra, Herbst Andreas, Bründl Elisabeth, Kagerbauer Simone Maria, Martin Jan, Lohmeier Anette, Stoerr Eva-Maria, Proescholdt Martin, Neuropeptide Y – an early biomarker for cerebral vasospasm after aneurysmal subarachnoid hemorrhage, Neurological Research, 35, 10, 2013. Crossref

  4. Mikami Norihisa, Miyagi Yayoi, Sueda Kaori, Takatsuji Miku, Fukada So-ichiro, Yamamoto Hiroshi, Tsujikawa Kazutake, Calcitonin Gene-Related Peptide and Cyclic Adenosine 5′-Monophosphate/Protein Kinase A Pathway Promote IL-9 Production in Th9 Differentiation Process, The Journal of Immunology, 190, 8, 2013. Crossref

  5. Nile Shivraj Hariram, Liang Yi, Wang Zengyuan, Zheng Jiayi, Sun Chengtao, Nile Arti, Patel Gopal, Kai Guoyin, Chemical composition, cytotoxic and pro-inflammatory enzyme inhibitory properties of Withania somnifera (L.) Dunal root extracts, South African Journal of Botany, 2021. Crossref

  6. Sato Tadasu, Yajima Takehiro, Saijyo Shiori, Shimazaki Kenichiro, Nishitani Tomiko, Hoshika Tomohiro, Nishitani Yoshihiro, Ichikawa Hiroyuki, Mizoguchi Itaru, Fukunaga Tomohiro, Distribution of alpha-synuclein in the rat cranial sensory ganglia, and oro-cervical regions, Annals of Anatomy - Anatomischer Anzeiger, 238, 2021. Crossref

  7. Zhang Yue, Zhang Hanyi, Jiang Boyue, Tong Xiaoliang, Yan Siyu, Lu Jianyun, Current views on neuropeptides in atopic dermatitis, Experimental Dermatology, 30, 11, 2021. Crossref

  8. Cornejo-García José Antonio, Liou Lieh-Bang, Blanca-López Natalia, Doña Inmaculada, Chen Chien-Hsiun, Chou Yi-Chun, Chuang Hui-Ping, Wu Jer-Yuarn, Chen Yuan-Tsong, Plaza-Serón María del Carmen, Mayorga Cristobalina, Guéant-Rodríguez Rosa María, Lin Shih-Chang, Torres María José, Campo Paloma, Rondón Carmen, Laguna José Julio, Fernández Javier, Guéant Jean-Louis, Canto Gabriela, Blanca Miguel, Lee Ming Ta Michael, Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations, Pharmacogenomics, 14, 15, 2013. Crossref

  9. Ding Wanhong, Stohl Lori L., Saab Jad, Azizi Shayan, Zhou Xi K., Mehta Devina, Granstein Richard D., Regulation of Cutaneous Immunity In Vivo by Calcitonin Gene–Related Peptide Signaling through Endothelial Cells, The Journal of Immunology, 208, 3, 2022. Crossref

  10. Slominski Andrzej T., Slominski Radomir M., Raman Chander, Chen Jake Y., Athar Mohammad, Elmets Craig, Neuroendocrine signaling in the skin with a special focus on the epidermal neuropeptides, American Journal of Physiology-Cell Physiology, 323, 6, 2022. Crossref

Forthcoming Articles

Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Effect of p-estrogen receptor at serine on its function and breast growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain