Library Subscription: Guest
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections
Critical Reviews™ in Immunology
IF: 1.404 5-Year IF: 3.347 SJR: 0.706 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Volumes:
Volume 40, 2020 Volume 39, 2019 Volume 38, 2018 Volume 37, 2017 Volume 36, 2016 Volume 35, 2015 Volume 34, 2014 Volume 33, 2013 Volume 32, 2012 Volume 31, 2011 Volume 30, 2010 Volume 29, 2009 Volume 28, 2008 Volume 27, 2007 Volume 26, 2006 Volume 25, 2005 Volume 24, 2004 Volume 23, 2003 Volume 22, 2002 Volume 21, 2001 Volume 20, 2000 Volume 19, 1999 Volume 18, 1998 Volume 17, 1997 Volume 16, 1996 Volume 15, 1995 Volume 14, 1994

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v26.i3.40
pages 265-290

T-Cell Receptor Signaling Events Triggering Granule Exocytosis

Sasa Radoja
Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970
Alan B. Frey
Department of Cell Biology and Kaplan Cancer Center, New York University School of Medicine, 550 First Avenue, New York, NY 10016
Stanislav Vukmanovic
Center for Cancer and Immunology Research, Children's Research Institute, Children's National Medical Center, 111 Michigan Avenue NW, Washington, DC 20010-2970

ABSTRACT

T-cell receptor (TCR) engagement by antigen results in proliferation, differentiation and cytokine secretion. In the CD8+ T-cell subset, TCR triggering also induces granule exocytosis, the directional release of contents of lysosome-like granules toward the target cell presenting the antigen. This process is responsible for immediate death of target cells. The intracellular events required for granule exocytosis are distinct from those of proliferation and cytokine secretion, as the former do not require de novo protein synthesis. Consequently, the key TCR signaling events required for granule exocytosis may be distinct. In this article, we review present knowledge of regulation of granule exocytosis by molecules of the TCR signaling cascade.


Articles with similar content:

Proteases and Cell-Mediated Cytotoxicity
Critical Reviews™ in Immunology, Vol.18, 1998, issue 3
R. Chris Bleackley, Alison J. Darmon
Interactions of Migrating T Lymphocytes, Inflammatory Mediators, and the Extracellular Matrix
Critical Reviews™ in Immunology, Vol.15, 1995, issue 3-4
Rami Hershkoviz, Sylvia G. Kachalsky, Ofer Lider
Is the CD200/CD200 Receptor Interaction More Than Just a Myeloid Cell Inhibitory Signal?
Critical Reviews™ in Immunology, Vol.26, 2006, issue 3
Janet Liversidge, Konstantinos Minas
Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions
Critical Reviews™ in Immunology, Vol.38, 2018, issue 6
Jacek Malejczyk, Agata Bialoszewska
Biological Function of HLA-DO (H2-O)
Critical Reviews™ in Immunology, Vol.34, 2014, issue 3
Xinjian Chen, Peter E. Jensen