Published 6 issues per year
ISSN Print: 1040-8401
ISSN Online: 2162-6472
Indexed in
Human Cytomegalovirus Persists in Its Host and Attacks and Avoids Elimination by the Immune System
ABSTRACT
Human cytomegalovirus (HCMV) is a herpesvirus that infects, and is carried by, 70%−100% of the world's population. During its evolution, the virus has adapted to survive in an immunocompetent host. For many years, HCMV was not considered to be a major human pathogen because it only caused rare cases of HCMV inclusion disease in neonates. However, HCMV is poorly adapted to survive in the immunosuppressed host and has emerged as an important human pathogen in AIDS patients, and in patients undergoing immunosuppressive therapy after organ or bone marrow transplantation. The virus is also the major infectious cause of birth defects. To coexist with its host, HCMV must avoid elimination by the immune system. Research over the past decade has revealed sophisticated mechanisms that enable the virus to remain invisible to cells of the immune system.
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Dzabic Mensur, Boström Lennart, Rahbar Afsar, High prevalence of an active cytomegalovirus infection in the appendix of immunocompetent patients with acute appendicitis, Inflammatory Bowel Diseases, 14, 2, 2008. Crossref
-
Esteki-Zadeh Atosa, Karimi Mohsen, Strååt Klas, Ammerpohl Ole, Zeitelhofer Manuel, Jagodic Maja, Mehrab-Mohseni Marjan, Sjöholm Louise, Rahbar Afsar, Söderberg-Nauclér Cecilia, Ekström Tomas J., Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity, Epigenetics, 7, 6, 2012. Crossref
-
Görzer Irene, Kerschner Heidrun, Jaksch Peter, Bauer Claudia, Seebacher Gernot, Klepetko Walter, Puchhammer-Stöckl Elisabeth, Virus load dynamics of individual CMV-genotypes in lung transplant recipients with mixed-genotype infections, Journal of Medical Virology, 80, 8, 2008. Crossref
-
Schleiss Mark R, HIV and cytomegalovirus co-infection in congenitally infected children: copathogens fanning each other's flames?, AIDS, 23, 16, 2009. Crossref
-
Nguyen Minh, Bradford Kara, Zhang Xiaolan, Shih David Q., Cytomegalovirus Reactivation in Ulcerative Colitis Patients, Ulcers, 2011, 2011. Crossref
-
Fischler Björn, Svensson Jan F, Nemeth Antal, Early cytomegalovirus infection and the long-term outcome of biliary atresia, Acta Paediatrica, 98, 10, 2009. Crossref
-
Söderberg-Nauclér Cecilia, Treatment of cytomegalovirus infections beyond acute disease to improve human health, Expert Review of Anti-infective Therapy, 12, 2, 2014. Crossref
-
de Matos Sócrates Bezerra, Meyer Roberto, Lima Fernanda Washington de Mendonça, Seroprevalence and serum profile of cytomegalovirus infection among patients with hematologic disorders in Bahia State, Brazil, Journal of Medical Virology, 83, 2, 2011. Crossref
-
Vali Bahareh, Jones R. Brad, Sakhdari Ali, Sheth Prameet M., Clayton Kiera, Yue Feng-Yun, Gyenes Gabor, Wong David, Klein Marina B., Saeed Sahar, Benko Erika, Kovacs Colin, Kaul Rupert, Ostrowski Mario A., HCV-specific T cells in HCV/HIV co-infection show elevated frequencies of dual Tim-3/PD-1 expression that correlate with liver disease progression, European Journal of Immunology, 40, 9, 2010. Crossref
-
Kim You Sun, Kim Young-Ho, Kim Joo Sung, Jeong Seong Yeon, Park Soo Jeong, Cheon Jae Hee, Ye Byong Duk, Jung Sung-Ae, Park Young Sook, Choi Chang Hwan, Kim Kyeung Ok, Jang Byung Ik, Han Dong Soo, Yang Suk-Kyun, Kim Won Ho, Long-Term Outcomes of Cytomegalovirus Reactivation in Patients with Moderate to Severe Ulcerative Colitis: A Multicenter Study, Gut and Liver, 8, 6, 2014. Crossref
-
Herberth Johann, Alimov Alexander P., Williams John P., Malluche Hartmut H., Koszewski Nicholas J., PTH regulation of the human cytomegalovirus immediate-early gene promoter, Biochemical and Biophysical Research Communications, 368, 4, 2008. Crossref
-
Söderberg-Nauclér Cecilia, HCMV microinfections in inflammatory diseases and cancer, Journal of Clinical Virology, 41, 3, 2008. Crossref
-
Hollink N., Dzabic M., Wolmer N., Boström L., Rahbar A., High prevalence of an active human cytomegalovirus infection in patients with colonic diverticulitis, Journal of Clinical Virology, 40, 2, 2007. Crossref
-
Emery V. C., Cytomegalovirus: recent progress in understanding pathogenesis and control, QJM, 105, 5, 2012. Crossref
-
Ernberg Ingemar, Karimi Mohsen, Ekström Tomas J., Epigenetic mechanisms as targets and companions of viral assaults, Annals of the New York Academy of Sciences, 1230, 1, 2011. Crossref
-
Sester U., Presser D., Dirks J., Gärtner B. C., Köhler H., Sester M., PD-1 Expression and IL-2 Loss of Cytomegalovirus- Specific T Cells Correlates with Viremia and Reversible Functional Anergy, American Journal of Transplantation, 8, 7, 2008. Crossref
-
Kofman Alexander, Marcinkiewicz Lucasz, Dupart Evan, Lyshchev Anton, Martynov Boris, Ryndin Anatolii, Kotelevskaya Elena, Brown Jay, Schiff David, Abounader Roger, The roles of viruses in brain tumor initiation and oncomodulation, Journal of Neuro-Oncology, 105, 3, 2011. Crossref
-
Ohlin Mats, Söderberg-Nauclér Cecilia, Human antibody technology and the development of antibodies against cytomegalovirus, Molecular Immunology, 67, 2, 2015. Crossref
-
Cederarv Madeleine, Söderberg-Nauclér Cecilia, Odeberg Jenny, HCMV infection of PDCs deviates the NK cell response into cytokine-producing cells unable to perform cytotoxicity, Immunobiology, 214, 5, 2009. Crossref
-
Söderberg-Nauclér Cecilia, Fornara Olesja, Rahbar Afsar, Cytomegalovirus driven immunosenescence—An immune phenotype with or without clinical impact?, Mechanisms of Ageing and Development, 158, 2016. Crossref
-
Freeman Michael L., Lederman Michael M., Gianella Sara, Partners in Crime: The Role of CMV in Immune Dysregulation and Clinical Outcome During HIV Infection, Current HIV/AIDS Reports, 13, 1, 2016. Crossref
-
Christensen-Quick Aaron, Vanpouille Christophe, Lisco Andrea, Gianella Sara, Cytomegalovirus and HIV Persistence: Pouring Gas on the Fire, AIDS Research and Human Retroviruses, 33, S1, 2017. Crossref
-
Söderberg-Nauclér Cecilia, Cytomegalovirus in human brain tumors: Role in pathogenesis and potential treatment options, World Journal of Experimental Medicine, 5, 1, 2015. Crossref
-
Travi Giovanna, Pergam Steven A., Cytomegalovirus Pneumonia in Hematopoietic Stem Cell Recipients, Journal of Intensive Care Medicine, 29, 4, 2014. Crossref
-
Stangherlin Lucas M., de Paula Felipe N., Icimoto Marcelo Y., Ruiz Leonardo G. P., Nogueira Maurício L., Braz Antônio S. K., Juliano Luiz, da Silva Maria C. C., Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency, Frontiers in Microbiology, 8, 2017. Crossref
-
Ivanusic Daniel, Pietsch Heiko, König Jasper, Denner Joachim, Pöhlmann Stefan, Absence of IL-10 production by human PBMCs co-cultivated with human cells expressing or secreting retroviral immunosuppressive domains, PLOS ONE, 13, 7, 2018. Crossref
-
Johnsen John Inge, Baryawno Ninib, Söderberg-Nauclér Cecilia, Is human cytomegalovirus a target in cancer therapy?, Oncotarget, 2, 12, 2011. Crossref
-
Vidal S.M., Malo D., Marquis J.-F., Gros P., Forward Genetic Dissection of Immunity to Infection in the Mouse, Annual Review of Immunology, 26, 1, 2008. Crossref
-
Yaiw Koon-Chu, Ovchinnikova Olga, Taher Chato, Mohammad Abdul-Aleem, Davoudi Belghis, Shlyakhto Eugene, Rotar Oxana, Konradi Alexandra, Wilhelmi Vanessa, Rahbar Afsar, Butler Lynn, Assinger Alice, Söderberg-Nauclér Cecilia, High prevalence of human cytomegalovirus in carotid atherosclerotic plaques obtained from Russian patients undergoing carotid endarterectomy, Herpesviridae, 4, 1, 2013. Crossref
-
Vider-Shalit Tal, Fishbain Vered, Raffaeli Shai, Louzoun Yoram, Phase-Dependent Immune Evasion of Herpesviruses, Journal of Virology, 81, 17, 2007. Crossref
-
Brennan Rebekah M., Miles John J., Silins Sharon L., Bell Melissa J., Burrows Jacqueline M., Burrows Scott R., Predictable αβ T-Cell Receptor Selection toward an HLA-B*3501-Restricted Human Cytomegalovirus Epitope, Journal of Virology, 81, 13, 2007. Crossref
-
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-
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