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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Immunopathogenesis of the Anti-Synthetase Syndrome

Volume 38, Issue 4, 2018, pp. 263-278
DOI: 10.1615/CritRevImmunol.2018025744
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ABSTRACT

Among the inflammatory myopathies, anti-tRNA-synthetase syndrome (ASyS) is a severe autoimmune condition characterized by extramuscular involvement, affecting especially the lungs. ASyS specific serological markers are anti-tRNA-synthetase autoantibodies, among which anti-histidyl-tRNA-synthetase is the most common. In the past decades, ASyS has been distinguished by unique histological features attributed to a specific pathogenesis. Research has highlighted the role of environmental factors and infections as possible triggers. Tissue modifications of histidyl-tRNA-synthetase (HisRS) expression might be responsible for the recruitment and activation of both innate and adaptive immune cells. HisRS not only acts through antigenic properties, but also through many others, including chemoattraction, innate pathway activation, and cytokine-like functions. Favored by a certain genetic background, this whole activation of immunity results in widespread and specific tissue damage and finally leads to visible heterogeneous symptoms characterizing the disease state. Understanding the pathogenesis of ASyS is essential to improving patient care by identifying biomarkers and designing new therapeutic strategies accordingly. Therefore, this review details the recent hypotheses concerning the dynamic of ASyS pathogenesis with the aim of enlightening the development of new therapeutic axes in the future.

CITED BY
  1. Hervier Baptiste, Uzunhan Yurdagül, Inflammatory Myopathy-Related Interstitial Lung Disease: From Pathophysiology to Treatment, Frontiers in Medicine, 6, 2020. Crossref

  2. Preuße Corinna, Paesler Barbara, Nelke Christopher, Cengiz Derya, Müntefering Thomas, Roos Andreas, Amelin Damien, Allenbach Yves, Uruha Akinori, Dittmayer Carsten, Hentschel Andreas, Pawlitzki Marc, Hoffmann Sarah, Timm Sara, Louis Sarah Leonard, Dengler Nora F., Wiendl Heinz, Lünemann Jan D., Sickmann Albert, Hervier Baptiste, Meuth Sven G., Schneider Udo, Schänzer Anne, Krause Sabine, Tomaras Stylianos, Feist Eugen, Hasseli Rebecca, Goebel Hans-Hilmar, Gallay Laure, Streichenberger Nathalie, Benveniste Olivier, Stenzel Werner, Ruck Tobias, Skeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis, Acta Neuropathologica, 144, 2, 2022. Crossref

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