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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v22.i2.10
10 pages

Regulation of Macrophage-Derived Chemokine (MDC/ CCL22) Production

Uki Yamashita
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
Etsushi Kuroda
Department of Immunology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan


Macrophage-derived chemokine (MDC, CCL22) is a member of the CC-chemokine family and is composed of 69 amino acid residues. MDC is mainly produced by macrophages and dendritic cells upon the stimulation with microbial products, or anti-CD40 antibody, and is upregulated by TH2-type cytokines, such as IL-4 and -5, but is downregulated by TH1-type cytokines, such as IFN-g. MDC-production is also upregulated by prostaglandin and cyclic AMP-elevating agents. MDC causes chemotactic migration of dendritic cells and ТH2 cells. Furthermore, MDC is highly-expressed in the lesions of TH2-related diseases, such as airway hypersensitivity and atopic dermatitis. Thus, MDC plays an important role in the recruitment of TH2 cells into the inflammatory sites and the regulation of TH2-related immune responses.

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