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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Maintenance and Attrition of T-Cell Memory

Volume 23, Issue 1-2, 2003, 20 pages
DOI: 10.1615/CritRevImmunol.v23.i12.70
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ABSTRACT

After antigenic stimulation in the context of "danger signals," naive T cells embark on a programmed, intense expansion phase to counteract the rapid proliferation of pathogens. During the first week of infection, responding T cells undergo >1000-fold expansion, resulting in the development of large numbers of cells exhibiting potent effector function. As the pathogen (antigen) burden dwindles, a majority of the effectors generated are eliminated by apoptosis, resulting in the survival and maintenance of a small population of antigen-specific cells as long-term memory T cells. Depending on the infection studied, CD8+ T cells appear to differentiate through multiple pathways into resting and effector memory subsets, and require multiple cytokines and cell surface molecules for survival and proliferation. Once generated, the repertoire of memory T cells remains highly vulnerable to attrition during heterologous infections, where homeostatic forces drive deletions in T-cell memory pools to accommodate the entry of new memory T cells. This review will primarily focus on the factors that influence the generation, maintenance, and attrition of memory CD8+ T cells.

CITED BY
  1. Ruby Carl E., Redmond William L., Haley Daniel, Weinberg Andrew D., Anti-OX40 stimulationin vivo enhances CD8+ memory T cell survival and significantly increases recall responses, European Journal of Immunology, 37, 1, 2007. Crossref

  2. Riou Catherine , Yassine-Diab Bader , Van grevenynghe Julien , Somogyi Roland , Greller Larry D. , Gagnon Dominic , Gimmig Sylvain , Wilkinson Peter , Shi Yu , Cameron Mark J. , Campos-Gonzalez Roberto , Balderas Robert S. , Kelvin David , Sekaly Rafick-Pierre , Haddad Elias K. , Convergence of TCR and cytokine signaling leads to FOXO3a phosphorylation and drives the survival of CD4+ central memory T cells , Journal of Experimental Medicine, 204, 1, 2007. Crossref

  3. Krishnan Lakshmi, Sprott G. Dennis, Archaeosome adjuvants: Immunological capabilities and mechanism(s) of action, Vaccine, 26, 17, 2008. Crossref

  4. Stark Felicity C., Gurnani Komal, Sad Subash, Krishnan Lakshmi, Teague Ryan M., Lack of Functional Selectin Ligand Interactions Compromises Long Term Tumor Protection by CD8+ T Cells, PLoS ONE, 7, 2, 2012. Crossref

  5. Maile Robert, Siler Catherine A., Kerry Samantha E., Midkiff Katherine E., Collins Edward J., Frelinger Jeffrey A., Peripheral “CD8 Tuning” Dynamically Modulates the Size and Responsiveness of an Antigen-Specific T Cell Pool In Vivo, The Journal of Immunology, 174, 2, 2005. Crossref

  6. Peacock Craig D., Welsh Raymond M., Origin and Fate of Lymphocytic Choriomeningitis Virus-Specific CD8+ T Cells Coexpressing the Inhibitory NK Cell Receptor Ly49G2 , The Journal of Immunology, 173, 1, 2004. Crossref

  7. Krishnan Lakshmi, Gurnani Komal, Dicaire Chantal J., van Faassen Henk, Zafer Ahmed, Kirschning Carsten J., Sad Subash, Sprott G. Dennis, Rapid Clonal Expansion and Prolonged Maintenance of Memory CD8+T Cells of the Effector (CD44highCD62Llow) and Central (CD44highCD62Lhigh) Phenotype by an Archaeosome Adjuvant Independent of TLR2, The Journal of Immunology, 178, 4, 2007. Crossref

  8. Miyahara Nobuaki, Gelfand Erwin W., CD8+ T Cells Play a Key Role in the Development of Allergic Lung Inflammation, in Allergy Frontiers: Classification and Pathomechanisms, 2, 2009. Crossref

  9. Lanfermeijer Josien, Borghans José A. M., Baarle Debbie, How age and infection history shape the antigen‐specific CD8 + T‐cell repertoire: Implications for vaccination strategies in older adults , Aging Cell, 19, 11, 2020. Crossref

  10. Lanfermeijer Josien, de Greef Peter C., Hendriks Marion, Vos Martijn, van Beek Josine, Borghans José A. M., van Baarle Debbie, Age and CMV-Infection Jointly Affect the EBV-Specific CD8+ T-Cell Repertoire, Frontiers in Aging, 2, 2021. Crossref

  11. Stark Felicity C., Sad Subash, Krishnan Lakshmi, Intracellular Bacterial Vectors That Induce CD8+ T Cells with Similar Cytolytic Abilities but Disparate Memory Phenotypes Provide Contrasting Tumor Protection, Cancer Research, 69, 10, 2009. Crossref

  12. de Titta Alexandre, Ballester Marie, Julier Ziad, Nembrini Chiara, Jeanbart Laura, van der Vlies André J., Swartz Melody A., Hubbell Jeffrey A., Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose, Proceedings of the National Academy of Sciences, 110, 49, 2013. Crossref

  13. Vezys Vaiva, Yates Andrew, Casey Kerry A., Lanier Gibson, Ahmed Rafi, Antia Rustom, Masopust David, Memory CD8 T-cell compartment grows in size with immunological experience, Nature, 457, 7226, 2009. Crossref

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