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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

The Repertoire of T-Cell Receptors in Systemic Sclerosis

Volume 15, Issue 2, 1995, pp. 155-165
DOI: 10.1615/CritRevImmunol.v15.i2.30
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ABSTRACT

Certain T cell subsets are increased in systemic sclerosis patients, particularly Vδ1+ γδ T cells in the blood and lungs and CD8+ αβ T cells in the lungs. The repertoires of T cell antigen receptor (TCR) Vδl, Vα, and Vβ gene families were examined by two methods of analysis. First, the relative abundance of Vα and Vβ gene transcripts was determined in the blood and bronchoalveolar fluid of the patients. Second, the diversity of the junctional regions in TCR Vδl transcripts and in different Vα and Vβ gene families was analyzed. Limited Vδ-Cδ junctional region lengths were observed in the patients compared with controls. This was confirmed by sequence analysis of Vδ1-Cδ junctional regions after subcloning amplified products in a bacterial vector. Evidence for selection of the Vδl+ T cells in the tissues of patients came from the findings that the same Vδ1-Cδ junctional sequences persisted in an individual patient over time and that identical junctional sequences were isolated from multiple sites. A restricted diversity of the junctional region lengths was also detected in a number of Vα and Vβ gene families, particularly within bronchoalveolar CD8+ T cell subset. These data suggest that the oligoclonal expansion of the corresponding αβ and γδ T cells is antigen-driven and may be important in the pathogenesis of systemic sclerosis.

CITED BY
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  2. Farge Dominique, Henegar Corneliu, Carmagnat Maryvonnick, Daneshpouy Marjan, Marjanovic Zora, Rabian Claire, Ilie Doina, Douay Corinne, Mounier Nicolas, Clave Emmanuel, Bengoufa Djaouida, Cabane Jean, Marolleau Jean Pierre, Gluckman Eliane, Charron Dominique, Toubert Antoine, Analysis of immune reconstitution after autologous bone marrow transplantation in systemic sclerosis, Arthritis & Rheumatism, 52, 5, 2005. Crossref

  3. Spontaneous Canine Model of Alopecia Areata, in Animal Models of Human Inflammatory Skin Diseases, 2003. Crossref

  4. Haustein U.-F., Anderegg U., Pathophysiology of scleroderma: an update, Journal of the European Academy of Dermatology and Venereology, 11, 1, 1998. Crossref

  5. Haustein Uwe-Frithjof, Systemic Sclerosis - An Update, Laboratory Medicine, 42, 9, 2011. Crossref

  6. Silver Richard M., CLINICAL PROBLEMS, Rheumatic Disease Clinics of North America, 22, 4, 1996. Crossref

  7. Tsukamoto H., Nagafuji K., Horiuchi T., Mitoma H., Niiro H., Arinobu Y., Inoue Y., To K., Miyamoto T., Iwasaki H., Teshima T., Harada M., Akashi K., Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells, Rheumatology, 50, 5, 2011. Crossref

  8. Farge Dominique, Nash Richard, Farge Dominique, Nash Richard, Laar Jacob M., Farge Dominique, Nash Richard, Laar Jacob M., Autologous stem cell transplantation for systemic sclerosis, Autoimmunity, 41, 8, 2008. Crossref

  9. Dana Reza, Chong Eva-Marie, Foster C. Stephen, Scleroderma, in Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology, 2008. Crossref

  10. Foster C. Stephen, Papaliodis George N., Drenen Kayla, Walsh Marisa, Scleroderma, in Albert and Jakobiec's Principles and Practice of Ophthalmology, 2021. Crossref

  11. Foster Charles Stephen, Papaliodis George N., Drenen Kayla, Walsh Marisa, Scleroderma, in Albert and Jakobiec's Principles and Practice of Ophthalmology, 2022. Crossref

  12. Sakkas Lazaros I., Tourtellotte Charles, Berney Steve, Myers Allen R., Platsoucas Chris D., Increased Levels of Alternatively Spliced Interleukin 4 (IL-4δ2) Transcripts in Peripheral Blood Mononuclear Cells from Patients with Systemic Sclerosis, Clinical Diagnostic Laboratory Immunology, 6, 5, 1999. Crossref

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