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Critical Reviews™ in Immunology
IF: 1.352 5-Year IF: 3.347 SJR: 1.022 SNIP: 0.55 CiteScore™: 2.19

ISSN Print: 1040-8401
ISSN Online: 2162-6472

Critical Reviews™ in Immunology

DOI: 10.1615/CritRevImmunol.v18.i6.50
pages 569-594

CD4+ T Cells Orchestrate Both Amplification and Deletion of CD8+T Cells

Loredana Frasca
Department of Cellular and Developmental Biology, "La Sapienza" University of Rome, Via degli Apuli 1, 00185, Rome, Italy
Cinzia Piazza
Department of Cellular and Developmental Biology, "La Sapienza" University of Rome, Via degli Apuli 1, 00185, Rome, Italy
Enza Piccolella
Department of Cellular and Developmental Biology, "La Sapienza" University of Rome, Via degli Apuli 1, 00185, Rome, Italy

ABSTRACT

This review focuses on the role of CD4+ T cells in regulating immune responses, orchestrating both the amplification and deletion of immune cells, particularly CD8+ T cells. These two functions, which represent only an apparent contradiction, appear to be two faces of the same process of regulation. In fact, because the immune response, once activated, needs to be carefully controlled or switched off when the antigenic stimulus is eliminated, the immune system has developed several strategies either to regulate clonal amplification or to avoid useless expansion of activated cells. In particular, we have reported many data demonstrating that CD4+ T cells may be indicated as the regulatory element in the activation as well as the deletion of CD8+T cells. New data are also reported on the ability of anergic CD4+ T cells to suppress CD8+ T-cell activation through induction of apoptosis, and on the need for CD8+ T cells for antigen recognition in inducing cell death in CD4+ T cells. Moreover, the central role of CD4+ T cells in the maintenance of peripheral tolerance has been widely described.


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