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Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

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Class II Antigen Processing: Analysis of Compartments and Functions

Volume 16, Issue 1, 1996, pp. 13-29
DOI: 10.1615/CritRevImmunol.v16.i1.20
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ABSTRACT

The endocytic and phagocytic pathways are composed of a series of vesicular or vacuolar organelles within the cytoplasm in which exogenous proteins or particles are processed. This processing includes catabolism of protein antigens by proteases that exist within endosomes, lysosomes, phagosomes, and phagolysosomes. Antigen processing produces peptides that bind to class II MHC (MHC-II) molecules, which also target to vesicular compartments. Multiple different vesicular compartments may contribute to antigen processing, although some compartments appear to be specialized in order to perform certain antigen processing functions. The relative levels of MHC-II molecules, processing enzymes, and other specialized molecules (e.g., HLA-DM) are among the variables that determine the relative contribution of different compartments. Recent studies have begun to identify specific compartments that mediate certain antigen processing functions, including the binding of immunogenic peptides to MHC-II molecules.

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